Functions performed by Natural Immune Modulating Components

Natural Immune Modulating Components & the Functions They Promote in the Body

Over 1,000 scientific studies demonstrating the Primary Functions Performed by the Natural Immune Modulating Components
1,000
In Contrast: Most “supplements” and pharmaceutical drugs have one or two studies supporting their limited functions.
2

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I, and a growing group of practitioners who are using the natural immune modulators, are watching while patients and people in the public eliminate some of the worst diseases known to man, which are all autoimmune and classified as “incurable”. See the outlined functions of the Natural Immune Modulating Components below, and corresponding scientific studies.


Actions of the natural aloe immune modulating micronutrients,
as demonstrated by science:
  1. Possess immune modulating and immune enhancing effects including, but not limited to: Normalization of cytokine profiles and over a 350% increase in pluripotent Stem Cells. This reduces or eliminates chronic inflammation and aids the body in healing damaged or defective tissues; even regenerate healthy new tissues. 1, 53, 54, 60, 61, 68, 70
  2. Increases numbers and activities of cytotoxic T-Lymphocytes. These are required for the destruction of viruses and abnormal cells. 2
  3. Increases Stem Cells counts by over 350%. This aids dramatically in the repair and regeneration of healthy new tissues. 3
  4. Increases numbers and activity of cytotoxic CD8 lymphocytes. These destroy bacterial and viral pathogens. 4
  5. Stimulates Immune System and Macrophages; producing Antibacterial and Antiviral effects. Polymannans activate the immune cascade, enabling the immune system to destroy bacteria, viruses, fungi and parasites as well as inactivate toxins and eliminate defective cells. 5, 6, 7, 55, 56 and 57.
  6. Suppresses pro-inflammatory cytokines TNF-a and IL-1B, which reduces or eliminates excessive acute and chronic inflammation; often related to the development and perpetuation of chronic diseases. 8
  7. Accelerated Wound healing was demonstrated in numerous studies. 9, 10, 11 and 12.
  8. Increased Phagocytosis and Candidacidal (antifungal) activity of Macrophages were demonstrated. This enhances the ability of macrophages, one of our first lines of defense, to destroy Candida, the pathogenic, disease causing fungi or yeasts. 13
  9. Tumor growth Inhibition was demonstrated 14. 34, 35, 36, 37, 38, 39
  10. Initiation of the Immune response; necessary for the immune system to perform it’s many and varied functions. 15
  11. Stimulation of the immune response and human cytokine production. These functions are necessary for the proper functioning of the immune system as well as regulating inflammation levels throughout the body. 27
  12. Increased numbers and activity of cytotoxic Human T lymphocytes. This study demonstrated increased numbers and activity of Human cytotoxic T lymphocytes which are essential to the destruction of viruses and abnormal cells throughout the body. 15
  13. Stimulation of monocytes and macrophages (release of cytokines). These immune related functions are essential for the maturation and differentiation as well as the activity of various immune cells so that they can perform their normal protective functions against foreign invaders such as bacteria, viruses, fungi and parasites. 15
  14. Stimulates natural immune killer cells (human). These cells protect us against viruses and help destroy abnormal cells. 20
  15. Accelerated wound healing and effectiveness in treating pressure ulcers in humans. 21
  16. Prevent virus penetration and stimulates the immune system.
  17. Dose dependent inhibition of HIV replication was proven. 24
  18. Low toxicity was proven; demonstrating the safety of the Immune Modulators. 26
  19. Stimulation of TNF-a, IL-1B, INF-y, IL-2 and Il-6 with a mannose-containing polysaccharide fraction; indicative of a dramatic increase in the immune response. 28
  20. Multiple Clinical studies prove the benefits of Aloe Polymannans to promote more rapid wound healing, (29), suppress allergy-based infections, (30, 31), are antiviral, (32, 33) and posses antitumor activity, (34, 35, 36, 37, 38, 39).
  21. Cell to Cell communication The structural orientation of glycoproteins in cell membranes is an important determinant in biochemical function. The peptide segment is extended into the cytosol toward the nucleus within the cytosol and the saccharide portion extends outwards from the cell surface. This orientation defines the primary role of the carbohydrate molecules in receptor-site structure and cell to cell adhesion and interactions. This explains why the proper terminal carbohydrate molecules determine the immune identity and cell to cell and immune system to cell interactions; the basis of cell to cell communication, which is so essential to optimal immune system functioning. 40
  22. The importance in cell biology of cellular surface saccharides, and especially mannose, and its low molecular weight and branched polymers cannot be overemphasized. 41
  23. Aloe Polymannans inhibit HIV-1 replication and infectivity as well as rendering the Newcastle and paramyxoviruses incapable of infecting cells and animals. These findings, among others, explain why HIV and other viral disease-infected patients and animals have greater resistance to infection and higher quality of life and life expectancy when taking the Polymannans immune modulators in therapeutic doses. 42, 43, 44
  24. Aloe Polymannans and structurally related activator molecules provide an activation signal to Monocytes and Macrophages for initiating cellular and humoral defensive activity. Aloe Polymannans have been shown to induce production (on a gradient basis), of IL-1B, PG-E2, IL-2, IL-6, TNF-alpha, GM-CSF, and INF-gamma. This demonstrates that these Aloe Polymannans initiate the host defense response which initiates the immune cascade, which begins, continues and completes the defense against invading disease-causing microorganisms, as well as initiating wound healing and other necessary immune system responses. 45
  25. Experience with rDNA (recombinant or GMO derived, DNA), technology-produced products of artificially produced cytokine activity have complications of antigenic stimulation related to their use. Contrary to these dangerous synthetic products, the endogenously (self) produced Cytokines, through natural means (by the use of the Stabilized Aloe Polymannans), are characterized by self-antigen signature, ultra-micro (low) dosing, up regulated or down regulated as required, and limited to the field of tissues invaded, damaged or ready for repair and which are not likely to induce an autoantibody reaction (as the synthetics often do). Aloe Polymannans polymers act as a biological response modifier that stimulates Monocytes and Macrophages in situ, (at the needed site), to enhance normal site and time response functions in diseased and healing tissues. This means that the synthetic (man-made) DNA (or other artificially produced), biological products often develop antigenic, or allergic, adverse reactions, whereas the naturally induced, locally acting and time and dose specific responses of the Aloe Polymannans are more effective and do not produce the dangerous “side effects” of the synthetic biologics. 46, 47, 48
  26. There are other serious problems reported with the use of rDNA (recombinant DNA)-engineered cytokines. Evidence has been provided that administration of rDNA-engineered interferon has resulted in antibody production in response to this foreign glycoprotein, resulting in the development of host (patient), antinuclear antibodies (ANA) and autoimmune thyroid disease (iatrogenic or doctor caused disease). 49, 50, 51
  27. Gene activation. Aloe Polymannans nutritionally supports leukocytic production of endogenous cytokines under control of the host’s genes (1) when, (2) where, and (3) in the amounts needed in response to molecular cues present in the cellular microenvironment, (site specific and time specific responses). Toxic and other untoward events are minimal due to the physiological and exquisitely targeted delivery of endogenously produced, potent, defensive cell products delivered in ultra-micro molecular amounts at the time dictated by tissue conditions. In the natural mannan polymer state produced by the aloe plant, there are a wide range of polymannose molecular weights that when phagocytized by monocytes and macrophages serve as a switch to initiate the aforementioned defense and healing activities through gene activation. The normal physiology of cellular biology is facilitated. 52
  28. Antidiabetic activity was demonstrated: 57, 58, 59, 69, 95 and 96
  29. Beneficial Effects on Allergies were demonstrated. 62
  30. Effectiveness of the Polymannans was demonstrated in treating HIV/AIDS. 64, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85 and 99.
  31. Benefits to gastrointestinal tract were documented by the Polymannans. 65, 66
  32. Gene Expression; (Epigenetic functions) were demonstrated by the Polymannans. 71
  33. Benefits to blood lipids and anti-atheromatous (reduction in atherosclerosis effects were observed with the use of the Polymannans. 69
  34. Enhanced Immune Function and Immunomodulation produced by the Aloe-derived Polymannans. 97, 98, 99 and 100.
  35. Increased Antioxidant function and Reduced Glutathione production by the Aloe-derived Polymannans. 101 and 102
  36. Anti-Aging Effects are Improved by a Polymannan Nutrient enhanced health plan. 103


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References:

  1. Lewis, et al, Miller School of Medicine Study: “ The Effects of an Aloe Polymannose Multinutrient Complex on Cognitive and Immune Functioning in Alzheimer’s Disease”. J. of Alzheimer’s disease, 33 (3013) 393-406 DOI 10.3233/JAD-2013 393-406 IOS Press 393, Jan-Feb 2013.
  2. Womble D Helderman JH. The impact of Acemannan on the generation and Function of Cytotoxic T-Lymphocytes. Immunopharmacol Immunotoxicol. 1992;14 (1-2):63—77.
  3. Lewis, et al, Miller School; of Medicine Study 1
  4. McDaniel HR, MD, Pathologist, Rosenberg LJ, PhD, McAnney BH, PhD. CD4 And CD8 lymphocytes levels in Acemannan (ACM) treated HIV-1infected long term survivors. Papers presented at: 9th International Conference on AIDS; 1993/06/06/, 1993.
  5. Peng, SY, Norman J, Curtin G, Corrier D, McDaniel HR, MD, Pathologist, Busbee D, PhD. Decreased Mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan. Mol Biother. 1991;3 (2): 79-87.
  6. Chinna AD, PhD, Baig MA, Tizard IR, PhD, Kemp MC, PhD. Antigen dependent adjuvant activity of a polydispersed beta-(1,4)-linked acetylated mannan (Acemannan). Vaccine. 1992; 10 (8): 551-557.
  7. Tizard IR, PhD. The effect of acemannan on the healing of wounds in experimental animals. Paper presented at: International Symposium on Wound Healing and Wound Management; 1992/10/10, 1992.
  8. Habeeb F, Stables G, Bradbury F, et al. The inner gel component of Aloe Vera suppresses bacteria-induced pro-inflammatory cytokines from human immune cells. Methods. 2007;42 (4):388-393.
  9. Fulton JE, Jr. The Stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. J Dermatol Surg Oncol. 1990; 16 (5):460-467.
  10. Parnell, LS, Chinnah A, Tizzard IR. The effect of an acetylated mannan on wound healing in guinea pigs. Paper presented at: European Tissue Repair Soceity;1992/08/26/ 1992.: Parnell LS,
  11. Chinnah A, Tizard IR. Accelerated Wound healing induced by a complex carbohydrate. Paper presented at: Wound healing Society Conference; 1992/04/, 1992.
  12. Swaim SF, Riddell KP, McGuire JA. Effects of Topical medications on the healing of open pad wounds in dogs. J AM Ani Hospital Assoc. 1992; 28 (November/December):499-502.
  13. Stuart RW, Lefkowitz DL, Lincoln JA, Howard K, Gelderman MP, Lefkowitz SS. Upregulation of phagocytosis and candidocidial activity of macrophages exposed to the immunostimulant acemannan. Int J Immunopharmacology. 1997;19(2):75-82.
  14. Akev N, Turkay G, Can A, et al. Effects of Aloe vera leaf pulp extract on Ehrlich ascites tumors in mice. Eur J Cancer Prev. 2007;16(2):151-157.
  15. Marshall GD, Gibbons AS, Parnell LS. Human cytokines induced by acemannan. Paper presented at: 50th annual meeting of the American Academy of Allergy and Immunology; 1993/03/12/, 1993.
  16. Zhang L, Tizard IR. Activation of mouse macrophage cell line by acemannan: THE MAJOR CARBOHYDRATE FRACTION FROM Aloe vera gel. Immunopharmacol. 1996;35(2):119-128.
  17. Marshall GD, Gibbons AS, Parnell LS. Human cytokines induced by acemannan. Paper presented at: 50th Annual Meeting of the American Academy of Allery and Immunology; 1993/03/12/, 1993.
  18. Womble D, Helderman JH. The impact of acemannan on the generation and function of cytotoxic T-lymphocytes. Immunopharmacol Immunotoxicol. 1992;14(1-2):63-77. 18, 20
  19. Thompson JE. Upper respiratory tract immunomodulator-acetyl mannan. AAOA Annual Meeting Program. Vol Minneapolis, MN 1993.
  20. Marshal GD, Druck JP. In vitro stimulation of NK activity by acemannan (ACM). Journal of Immunology. 1993;8(150):241—241. 20
  21. Mulder GD, Jensen JL, Seeley JE, Peak-Andrews K. A controlled, randomized study of an amorphous hydrogel to expedite closure of diabetic ulcers. Paper presented at: 4th European Conference on advances in Wound Management; 2006/09/06/09/1994, 1994.
  22. Thomas DR, Goode PS, LaMaster K, Tennyson T. Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial. Adv Wound Care. 1998;11(6):273-276.
  23. Clumeck N, Hermans P. Antiviral drugs other than zidovudine and immunomodulating therapies in human immunodeficiency virus infection. An overview. Am J Med. 1998;85(2A):165-172.
  24. Kahlon JB, Kemp MC, Carpenter RH, McNalley BH, McDaniel HR, Shannon WM. Inhibition of AIDS virus replication by acemannan in vitro. Mol Biother. 1991;3(3):127-135.
  25. McDaniel HR, MD, Pathologist, Combs C, Carpenter R, Kemp M, McNalley B, PhD. An increase in circulating monocyte/macrophages (M/M) is induced by oral acemannan (ACE-M) in HIV -1 patients. Paper presented at: American Society of Clinical Pathologists’ Fall Meeting; 1990/10/20, 1990.
  26. Ruedy J, Montaner JSG, Arseneau R, singer J, Gill J. Pilot study of acemannan effect on HIV patients with diminished response to AZT therapy, utilizing placebo control and double-blind design. Carrington Laboratories, Inc. Research and Development Division. 1300 East Rochelle Blvd., Irving, TX 75062: Carrington Labs, Inc.;1991. St. Paul’s Protocol J118/ Carrington Protocol 9501.
  27. Marshall GD, Gibbons AS, Parnell LS. Human cytokines induced by acemannan. Paper presented at: 50th Annual Meeting of the American Academy of Allergy and Immunology; 1993/03/12/, 1993.
  28. Leung, MY, Liu, C, Zhu LF, Hui YZ, Yu B, Fung KP. Chemical and biological characterization of a polysaccharide biological response modifier from aloe vera L. var. chinensis (Haw.) Berg. Glycobiology. 2004;14(6):501-510.
  29. Davis, RH, Donate, BA,Hartman GM, Haas, RC. Anti-inflammatory and Wound-Healing Activity of a Growth Substance in Aloe vera. JAPMA Vol. 84, No. 2, Feb. 1994.
  30. McAnalley, BH, PhD, McDaniel, MD, Pathologist, Carpenter, RH. Demonstration of In Vitro Antiviral action pf acemannan against Multiple Viruses Including HIV-1. 4th Int. Conf. AIDS, (abst/poster Vol. II, 3567) June 1988.
  31. Thompson JE. Upper Respiratory Tract Immune Modulator: Acetyl Mannan Am acad Oto Lary, (abst.) Vol. 10; 3, P.24, Sept. 1993.
  32. McNalley, BH., PhD, McDaniel, HR, MD, Pathologist, Carpenter, RH. Administration of acemannan: a method of activation, induction and enhancement of the production of cytokines. Reg. No. 5, 106, 616, April 21, 1992.
  33. Kent EM. Use of an immunostimulant as an aid in Treatment and Management of Fibrosarcoma in Three Cats, Feline Practice, Vol. 21, No. 6, Nov./Dec 1993.
  34. Mata JS. Selected Case Studies in skin and Wound C Treatment, Clinical Case Updates, Fix BM, Ed. Vol. 4 June 1993.
  35. Edmondson JH, Long HJ, Creagan ET. Et al. Phase II Study of recombinant gamma interferon in patients with advanced non-osseous sarcomas, Cancer Treat Rep 71:211-213, 1987.
  36. Merriam EA, Campbell BS, Flood LP, Welsh CJR, McDaniel, HR, MD, Pathologist, Busbee DL. Enhancement of Immune Function in Rodents Using a Complex Plant Carbohydrate Which Stimulates Macrophage Secretion of Immunointeractice Cytokines, Anti-aging Medicine Vol. 1, Mary Ann Liebert Pub., 1996.
  37. Sheets MA, Unger BA, Giggleman GF, Tizard IR, PhD. Studies of the Effects of Acemannan on virus infections: clinical stabilization of feline leukemia virus-infected cats, Mol. Biother., Vol. 3 41-45. Man 1991.
  38. Harris CH, Pierce K, Ging G, Yates KM, Hall J, Tizard I, PhD. Efficacy of Acemannan in Treatment of Canine and Feline Spontaneous Neoplasams, Mo. Biother., Vol. 3, Dec. 1991.
  39. king G, Yates K, Tizard I, PhD. Use of Acemannan as an aid in Treatment of Canine and Feline Fibrosarcoma, Am. Col. Vet. Surg. Symposium, San Francisco, 1991.
  40. Darnell J., Lodish H., Baltimore D. Ed. Molecular Cell Biology, Scientific American 1986.
  41. Kornfeld R, Kornfeld S. Assembly of Asparagine-linked Oligosaccharides, Ann Rev. Biochem. 31-664, 1985.
  42. Mitchell WM. In vitro Evaluation of Acemannan as an anti-HIV-1 Agent. Carrington Research report 4001. Dec. 1987.
  43. Kemp MC, Chinnah AD, McAnalley BH, PhD, Carpenter RH, McDaniel HR, MD, Pathologist. Effects of Acemannan on Replication of Enveloped Viruses. Intrascience Conf. Antimicrobial Agents and Chemotherapy, (abst/poster/oralNo. 505) Sept. 1989.
  44. Kemp MC, Chinnah AD, PhD, McAnalley BH. Evaluation of Polymannoacetate in the treatment of AIDS patients, (abst/poster) Clin res, Vol 35,No. 3 April 1987.
  45. Old L. Tumor necrosis Factor, Scientific American 75, 258 1988.
  46. Thompson JE. Upper Respiratory Tract Immune Modulator: Acetyl Mannan Am Acad Oto Lary. (abst.) Vol 10; 3, P 24, Sept. 1993
  47. Davis R H ,Donate BA, Hartman GM, Haas RC. Anti-inflammatory and Wound Healing Activity of a Growth Substance in Aloe Vera. JAPMA Vol. 84, No. 2, Feb 1994.
  48. Bigas MR, Cruz NL, Surarez A. Comparative Evaluation of Aloe Vera in the management of Burn Wounds in Guinea Pigs, Plast. Reconstruct. Surg, Vol. 81,No. 3, P. 386, 1988.
  49. USDA approval letter for injectable acemannan immunostimulant treatment as an aid in surgery and management of canine and feline fibrosarcoma sarcomas. Feb. 1991.
  50. 1991. Ronnblom LE, Aim GV, Oberg KE. Autoimmunity after alpha interferon therapy for malignant carcinoid tumors. Ann Inter Med.; 115; 178-183, 1991.
  51. Okun’H, Kitao Y, Takasu M, et al. Depression of drug metabolizing activity in the human liver by interferon-alpha. Eur J Clin Pharmacol. 39:365-367, 1990.
  52. From: “The Gift, A Primal Provision”, by H. R. McDaniel, MD, P. 82, 2007
  53. Suzuki, et al, 1979
  54. Aloe Vera and the Human Immune System, Dr. Lawrence Plaskett, B.A., PhD., C. Chem., F.R.S.C., Aloe Vera Information Service, Issue I.
  55. Antiviral Activity of Aloe Extracts against Cytomegalovirus; Dr. Wendell Winters.
  56. Bacteriostatic Property of Aloe Vera; Lorna J. Lorenzetti, Rupert Salisbury, Jack Beal & Jack N. Baldwin.
  57. Aloe Vera (Aloe Vera Barbadensis Miller), Internal Uses of Aloe Vera, Potential Benefits from Orally-Ingested Internal Aloe Vera Gel, Ivan E. Danhof, PhD., M.D.
  58. Antidiabetic activity of Aloe Vera Juice Clinical Trial in new cases of iabetes Mellitus. S. Yongchayudha, V. Rungpitaransi, N. Bunyapraphtarsa & O. Chokechaijaroenporn. Phytomedicine Vol. 3 (3), pp.241-243, 1996 by Gustav Fischer Verlag, Stuttgart-Jen-New York.
  59. Biological Activity of Aloe Vera; R.H. Davis.
  60. Aloe species have been reported to have several biological activities, including: immunomodulation; Suzuki, et al, 1979; Yoshimoto, et al, 1987; Winters, et al, 1981 Yagi, et al, 1985; and Saito, 1993, enhancement of wound healing (Heggars, et al, 1993) and anti-inflammatory actions ( Davis, et al, 1989).
  61. Aloe Vera (Aloe Barbadensis Miller); Ivan E. Danhof, PhD., M.D.
  62. Allergy and the Immune System; Lawrence M. Lichtenstein.
  63. a Clinical Study using Carrisyn in the treatment of Acquired Immune Deficiency Syndrome (AIDS); H. Reginald McDaniel, M.D., Sue Perkins & B.H, McNalley.
  64. Aloe Drug May Mimic AZT without Toxicity, Medical World News, Dec. 1987 issue, Dr. H., Reginald McDaniel, M.D.
  65. Effects of Orally Consumed Aloe Vera juice on Gastrointestinal Function in Normal Humans Jeffrey Bland, PhD., Linus Pauling Institute of Science and Medicine, Palo Alto, CA.
  66. evaluation of Acemannan in the Treatment of Recurrent Aphthouse Stomatitis; Jacqueline M. Plemons, Terry D. Rees, William H. Binnie, John M. Wright, Ingrid Guo & John E. Hall.
  67. Infectious Diseases; SD. Kaufman and D. Holland, M.D.
  68. Partial Purification and some Properties of an Antibacterial Compound from Aloe Vera; Hadassa Levin, R. Hazenfratz, J. Friedman, D. Paleovitch & M. Perl.
  69. Prevention of Atheromateous Heart disease, 1985 Aloe’s blood glucose lowering, cholesterol and triglyceride lowering effects, O.P. Agarwal, M.D., F.I.C.A., Uttar Pradesh, India: Angiology; Vol. 36, No. 8, August, 1985 – The Journal of Vascular Diseases, Wetminster Publications, Inc.
  70. The Conductor-Orchestrator Concept of Aloe Vera; Robert H. Davis, PhD., Scientific Advisor and Research Consultant, Professor Emeritus of Physiology, Pennsylvania College of Podiatric Medicine.
  71. “Nutrient Receptors and Gene Expression” Nutrition and Gene Expression, edited by Carolyn D. Berdainer and James L. Hargrove, Boca Raton, FL, CRC Press, 1993; Berdainer, Caroyln D., and James L. Hargrove.
  72. Evaluation of Polymannan Acetate in the Treatment of AIDS. McDaniel H R, McNalley B H. Clin Res. 1987, 35 (3).
  73. A Clinical Pilot Study Using Carrisyn TM in the Treatment of Acquired Immune Deficiency Syndrome. McDaniel HR,Perkins S., McNalley BH. Am. J. of Clinical Pathology, 1987. 88 (4):534.
  74. Inhibition of AIDS Virus Replication by Acemannan (R)., In Vitro. Kahlon JB, Kemp MC, Carpenter RH, McNally BH, McDaniel HR, Shannon WM. Molecular Biotherapy. Vol. 3, September, 1991.
  75. A Clinical Pilot Study Using Carrisyn TM (Acemannan®) Treatment of 16 Aquired Immunodeficiency Syndrome Patients. McDaniel HR, Perkins S, McAnalley BH. Texas Society of Pathologists Scientific Poster Presentation, Galvaston, Texas, Jan. 1988.
  76. Prediction and Results Obtained Using Oral Acemannan® in 41 Symptomatic HIV Patients. McDaniel HR, Pulse T, Watson T, et al.. Texas Society of Pathologists Scientific Poster Presentation, Galvaston, Texas, Jan. 1988.
  77. An Extended Clinical Pilot Study Utilizing Acemannan® in HIV Patients. McDaniel HR, Pulse T, McAnalley BH. The First International Conference on the Global Impact of AIDS, London, England, March 8-10, 1988.
  78. Objective Evidence of a Favorable Clinical Response to Acemannan®, a Biologic, In HIV-1 Patients. McDaniel H R, McAnalley BH, Carpenter RH. 16th International Congress of Chemotherapy, Israel, June 11-16, 1989.
  79. Dose Dependent Inhibition of HIV Replication in the Presence of Acemannan, in Vitro. Kahlon JB, McAnalley B H, McDaniel H R. International Symposium on Antiviral Chemotherapy, Sardina, Italy, Oct. 1-5, 1989.
  80. Effects of Acemannan on T Cell Proliferation & HIV-1?LAV Replication in vitro, Kahon J B, Kemp M, McDaniel HR. Sixth International Conference on Comparative and Applied Virology, Alberta, Canada, Oct. 15, 1989.
  81. In vitro Evaluation of the Antiviral Effects of Acemannan® on the Replication and Pathogenesis of HIV-1 and other Envelope Viruses: Modification of the Processing of Glycoprotein Precursors. Kemp M C, Kahlon, J B, Chinnah A D, Carpenter R H, Mc Annaly B H and McDaniel H R. Third Annual Conference on Antiviral Research, Brussels, Belgium, April 22-27, 1990.
  82. Extended Survival and Prognosis Criteria of Acemannan® Treated HIV-! Patients, McDaniel H R, Carpenter R H, Kemp M C, Kahlon, J B, McNallay B H. Third International Conference on Antiviral Research, Brussels, Belgium, April 22-27, 1990.
  83. HIV-1 Infected Patients Respond favorably to Oral Acemannan®. McDaniel H R, et al. Sixth International Conference on AIDS. San Fransisco, CA, June 20-24, 1990.
  84. Concentration Dependent Inhibition of AIDS Virus Replication and Pathogenesis by Acemannan® In vitro. McDaniel, et al. Sixth International Confrence on AIDS, San Fransisco, CA. June 20-24, 1990.
  85. Long-Term Survival of HIV Positive Patients Receiving Oral Acemannan®. McDaniel, H R, et al. Sixth International Conference on AIDS, San Fransisco, CA. June 20-24, 1990. Retrospective Survey, H.R. McDaniel, MD, PhD, et al, 6thInternational Congress on Anti-Aging & Bio-Medical Technology, Las Vegas, NV, Dec. 1998.
  86. CD4 and CD8 Lymphocyte Levels in Acemannan® -Treated patients with HIV-a Infected Long-Term Survivors. McDaniel H. R., Rosenberg LJ, McAnnalley B H. IXth International Conference on AIDS/HIV STD World Congress, Berlin, June, 1993.
  87. Aloe Polymannose Enhances Anti-coxsackie virus antibody Titres in Mice. C. J. Gauntt, H. J. Wood, H.R. McDanield, MD, B. H. McAnnelly
  88. Isolation and Characterization of a New Antiviral Polysaccharide Extracted from aloe Barbadensis Miller. Eberendu A R, Mcannelly BH, Carpenter RH and McDaniel HR. Texas Society of Pathologists Scientific Poster Presentation. Galverston, Texas, Jan. 1988.
  89. In Vitro Antiviral Effect of Acemannan® in Feline Rhinotracheitis. McDaniel H R, MD, White A, McAnnelly, B H, et al. Texas Society of Pathologists Scientific Poster Presentation. Galverston, Texas, Jan., 1988.
  90. In Vivo Antiviral Effect of Acemannan® in Feline Rhinotracheitis. McDaniel H R, MD, White A, McAnnelly, B H, et al. Texas Society of Pathologists Scientific Poster Presentation. Galverston, Texas, Jan., 1988.
  91. Antiviral Action of Acemannan® in a Measles Infected Cell Line. White A, McDaniel H R, McAnnelly B H, et al. Texas Society of Pathologists Scientific Poster Presentation, Galverston, Texas, Jan. 1988.
  92. Inhibition of Human T-Cell Lymphotrophic Virus In Vitro by Acemannan, McDaniel H R, McAnnelly, B H, et al. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, Jan., 1988.
  93. Modification of Viral Glycoprotein Synthesis by Acemannan®. McNalley, B H, and McDaniel H R and Carpenter R H. Fifth International Symposium on the Immunobiology of of Proteins and Peptides. Lake Louise, Alberta, Canada, Oct. 1988.
  94. General Antiviral Activity is Supported by Glyconutrient Dietary Supplementation. H R McDaniel, Luis Romero, Hepatis, 2000, Miami, Florida, June, 2000.
  95. Nutraceutical Dietary Supplementation Improves Clinical Status of Diabetics: A Retrospective Survey, H. R. McDaniel, MD, et al, 6th International Congress on Anti-Aging and Bio-Medical technology, Las Vegas, NV, Dec. 1998.
  96. Glyconutrients Increase Intracellular – Reduced Glutathione Levels Providing a Potential for Prevention and Reversal of Degenerative Processes Associated with Diabetes and Aging, H.R. McDaniel, MD, et al, 6th International Congress on Anti-aging and Bio-Medical technology, Las Vegas, NV, Dec. 1998.
  97. Enhancement of Immune Function in Rodents Using a Complex Plant Carbohydrate Which Stimulates Macrophage Secretion of Immunointeractive Cytokines. Merriam E A, et al. Advances in Anti-Aging Medicine Vol. 1, ed Ronald M. Klatz, D. O. Mary Ann Liebert, Inc., 1996.
  98. Evidence for Systemic Immunomodulation by acemannan®. Kemp M C, Chinnah A D, McAnnelly BH, McDaniel HR. Fifth International Symposium on the Immunobiology of Proteins and Peptides. Lake Louise, Alberta, Canada, October, 1988.
  99. An Increase in Circulating Monocyte/macrophages is Induced by Oral Acemannan(R) in HIV-1 patients. McDaniel H R, Combs C, Carpenter R H, Kemp M C, McNalley B H. American Society of Clinical pathologists Fall meeting, Dallas, Texas, October, 1990.
  100. An Open–Label, Randomized Clinical trial to assess the Immunomodulatory Activity of a Novel Oligosaccharide Compound in healthy Adults. Karriem H. Ali, Angelica B Melillo, Susanna M., Leonard, Deshram Asthana, Judi M. Woolger, Aaron H. Wolfson, H. Reginald McDaniel and John E. Lewis. Functional Foods in Health and Disease, 2012, Vol. 2, Issue 7 (July 28, 2012). Academy of Environmental Medicine, Baltimore, MD, Nov. 5-8. 1998.
  101. Glyconutrients Increase Reduced Glutathione Levels in Murine Liver Cells, H.R. McDaniel, et al, Indian health service 10th Annual Research Conference, Albuquerque, New Mexico, April, 1998. (Scientific Paper).
  102. Increased Intracellular Antioxidant Protection of Murine Liver Cells is induced by Glyconutrients, H R McDaniel, et al, The 33rd Annual Meeting of The American Academy of Environmental Medicine, Baltimore, MD, Nov. 5-8, 1998.
  103. Bio-Markers of Aging are Improved by a Nutraceutical-Augmented Optimum Health Plan, H R McDaniel, et al, 6thInternational Congress on Anti-Aging and Bio-Medical Technology, Los Vegas, NV, Dec., 1998.


See what the Patients say who take AUTOIMMUNE-X


Frequently Asked Questions about AUTOIMMUNE-X

Additional Supporting Documentation:

  1. A Clinical Pilot Study Using CarrisynTMin the Treatment of Acquired Immunodeficiency Syndrome.  McDaniel HR, Perkins S, McAnalley BH.  J. of Clinical Pathology, 1987, 88(4):534.
  2. A Book Review: Education’s Smoking Gun: National Monitor of Education, V.12, #7, March, 1989.
  3. Inhibition of AIDS Virus Replication by Acemannan, In Vitro. Kahlon JB, Kemp MC, Carpenter RH, McAnalley BH, McDaniel HR, Shannon WM.  Molecular Biotherapy, Vol. 3, September 1991.
  4. Decreased Mortality of Norman Murine Sarcoma in Mice Treated with the Immunomodulator, Acemmanan. Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D.  Bio., 3 June 1991.
  5. The Number of Circulating Macrophages in Peripheral Blood Have a Physiological Significance and Diagnostic Implications. McDaniel HR, Combs CM.  Laboratory Medicine, 1992.
  6. A Comparison of the Physicochemical Properties and Effectiveness of Commercial Wound Cleansers. Eberendu AR, McAnalley BH, McDaniel HR.  Journal of Surgical Research, August 10, 1992.
  7. Enhancement of Immune Function in Rodents Using a Complex Plant Carbohydrate Which Stimulates Macrophage Secretion of Immunointeractive Cytokines. Merriam EA, et al.  Advances in Anti-Aging Medicine Volume 1, ed. Ronald M. Klatz, D.O.  Mary Ann Liebert, Inc. 1996.
  8. A Phytochemical Vista: the role of micronutrients in health and restoration of health. R. McDaniel, B.H. McAnalley, Breakthroughs, Vol I, No.3., p 4-6. Fall, 1997.
  9. Aloe Polymannose Enhances Anti-coxsackievirus Antibody Titres in Mice. J. Gauntt, H.J. Wood, H.R. McDaniel, B.H. McAnalley
  10. Phase I of the Nutraceutical Intervention Longitudinal Trials: A Meta-Analysis of Short-term Changes in body Composition, G.R. Kaats, H. R. McDaniel, L.K. Parker, et.al. Fisher Proc. Med. Res. Vol 2, No.1., 2000.
  11. Mobilization of Diozin is Supported by Dietary supplements: A Case Study.  R. McDaniel, P.B. Stevens, Fisher Proc. Med. Res. Vol.2, No.2, 2001.
  12. Lipoprotein Electrophoresis Techniques, North Texas Area Medical Technologist, Fort Worth, Texas, November 1969.
  13. Lipid Profile Studies with Clinical Correlation, Texas Medical Association Annual Meeting, Dallas, Texas, May 1, 1970.
  14. AIDS Scientific Symposium and Industry Conference, Overview and Development Status of: Vaccines, Drugs and Diagnostics, March 13, 1987, Waldorf Astoria, New York, NY.
  15. Evaluation of Polymannoacetate in the Treatment of AIDS, McDaniel HR, McAnalley BH, Clinical Research, National Meeting, San Diego, Calif, May 1-4, 1987.
  16. A Clinical Pilot Study Using CarrisynTMin the Treatment of AIDS, In Vitro Polymannoacetate for Antiviral Effect, McDaniel HR, McAnalley, BH. American Society of Clinical Pathologists, 1987 Fall Meeting & Exhibits, Oct. 24 – 30, 1987.
  17. Isolation and Characterization of a New Antiviral Polysaccharide Extracted from Aloe Barbadensis Miller. Eberendu AR, McAnalley BH, Carpenter RH, McDaniel HR. Texas Society of Pathologists Scientific Poster Presentation. Galveston, Texas, January 1988.
  18. In Vitro Antiviral Effect of Acemannan on Feline Rhinotracheitis. McDaniel HR, White A, McAnalley BH, et al. Texas Society of Pathologists Scientific Poster Presentation.  Galveston, Texas, January 1988.
  19. In Vivo Antiviral Effect of Acemannan on Feline Rhinotracheitis. Carpenter RH, McDaniel HR, McAnalley BH, Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  20. Acemannan Demonstrated as an Immune Adjuvant for Viral Vaccinations of Animals. Carpenter RH, McDaniel HR, McAnalley BH. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  21. Antiviral Action of Acemannan in a Measles Infected Cell Line. White A, McDaniel HR, McAnalley BH, et al. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988
  22. Identification of a Gigantic Circulating Monocytic Cell in Warm-Blooded Animals. McDaniel HR, McAnalley BH, Carpenter RH, et al. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  23. The Significance of Identifying a Gigantic Circulating Cell in the Peripheral Blooded Animals. McDaniel HR, McAnalley BH, Carpenter RH. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  24. Inhibition of Human T-Cell Lymphotrophic Virus In Vitro by Acemannan. White A, McDaniel HR, McAnalley BH, et al. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  25. A Clinical Pilot Study Using Acemannan Treatment of 16 Acquired Immunodeficiency Syndrome Patients. McDaniel HR, Perkins S, McAnalley, BH. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  26. Prediction and Results Obtained Using Oral Acemannan in 41 Symptomatic HIV Patients. McDaniel HR, Pulse T, Watson T, et al.. Texas Society of Pathologists Scientific Poster Presentation, Galveston, Texas, January 1988.
  27. An Extended Clinical Pilot Study Utilizing Acemannan in HIV Patients. McDaniel HR, Pulse T, McAnalley BH. The First International Conference on the Global Impact of AIDS, London, England, March 8-10, 1988.
  28. Prediction & Results Obtained Using Oral Acemannan in 41 Symptomatic HIV Patients. McDaniel HR, Pulse T. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988.
  29. Clinical and Objective Evidence of a Favorable Response to Acemannan Treated HIV-1 Patients. McDaniel HR, Pulse T. The 1988 International Symposium on Medical Virology, San Francisco, California, September 22-24, 1988.
  30. Effect(s) of Acemannan on the Replication of Enveloped Viruses, Kemp M, McDaniel HR, McAnalley BH, Carpenter RH. 29th ICAAC, Houston, Texas, Sept. 17-20, 1989.
  31. Prognostic Criteria for Evaluating the Clinical Efficacy of Acemannan for the Treatment of Symptomatic HIV-1 Positive Patients. McDaniel HR, Pulse T, McAnalley BH, Watson T, Carpenter RH. 29th ICAAC, Houston, Texas, Sept. 17-20, 1989.
  32. Objective Evidence of a Favorable Clinical Response to Acemannan, A Biologic, In HIV-1 Patients. McDaniel HR, McAnalley BH, Carpenter RH. 16th International Congress of Chemotherapy, Jerusalem, Israel, June 11-16, 1989
  33. Dose Dependent Inhibition of HIV Replication in the Presence of Acemannan, in vitro. Kahlon JB, McAnalley BH, McDaniel HR. International Symposium on Antiviral Chemotherapy, Sardinia, Italy, Oct. 1-5, 1989.
  34. Effect of Acemannan on T-Cell Proliferation & HIV-1/LAV Replication in vitro, Kahlon JB, Kemp M, McDaniel HR.Sixth International Conference on Comparative & Applied Virology Alberta, Canada, October 15, 1989.
  35. In Vitro Evaluation of the Antiviral Effects of Acemannan on the Replication and Pathogenesis of HIV-1 and Other Enveloped Viruses: Modification of the Processing of Glycoprotein Precursors. Kemp MC, Kahlon JB, Chinnah AD, Carpenter RH, McAnalley BH, McDaniel HR. Third International Conference on Antiviral Research, Brussels, Belgium, April 22-27, 1990.
  36. Extended Survival and Prognostic Criteria for Acemannan Treated HIV-1 Patients, McDaniel HR, Carpenter RH, Kemp MC, Kahlon JB, McAnalley BH. Third International Conference on Antiviral Research, Brussels, Belgium, April 22-27, 1990.
  37. Modification of Viral Glycoprotein Synthesis by Acemannan. Kemp MC, Chinnah AD, McAnalley BH, McDaniel HR, Carpenter RH. Fifth International Symposium on the Immunobiology of Proteins and Peptides.  Lake Louise, Alberta Canada, October 1988.
  38. Evidence for Systemic Immunomodulation by Acemannan. Kemp MC, Chinnah AD, McAnalley BH, McDaniel HR, Carpenter RH. Fifth International Symposium on the Immunobiology of Proteins and Peptides.  Lake Louise, Alberta Canada, October 1988.
  39. HIV-1 Infected Patients Respond Favorably to Oral Acemannan. McDaniel HR, et al. Sixth International Conference on AIDS, San Francisco, California, June 20-24, 1990.
  40. Concentration Dependent Inhibition of AIDS Virus Replication and Pathogenesis by Acemannan®In Vitro. McDaniel HR, et al.  Sixth International Conference on AIDS, San Francisco, California, June 20-24, 1990.
  41. Long-Term Survival of HIV-Positive Patients Receiving Oral Acemannan. McDaniel HR, et al. Sixth International Conference on AIDS, San Francisco, California, June 20-24, 1990.
  42. Extended Treatment of HIV-1 Patients with Oral Acemannan: An Immune Modulator. McDaniel HR, Carpenter RH, Kemp MC, Kahlon JB.  International Symposium on Infections in the Immunocompromised Host.  Peebles, Scotland, June 1990.
  43. Clinical Testing and AIDS Treatment Experience With Acemannan: The Antiviral and Antitumor Immunomodulator Isolated From Aloe Barbadensis Miller, McDaniel HR, McAnalley BH. Zurcher AIDS Kongress, Zurich, Switzerland. Oct. 16-17, 1992.
  44. An Increase in Circulating Monocyte/Macrophages is Induced By Oral Acemannan in HIV-1 Patients. McDaniel HR, Combs C, McDaniel HRex, Carpenter RH, Kemp MC, McAnalley BH. American Society of Clinical Pathologists Fall Meeting, Dallas, Texas, October 1990.
  45. The Numbers of Circulating Monocyte/Macrophages in Peripheral Blood are of Diagnostic Significance. McDaniel HR, Combs C, McDaniel HRex, Carpenter RH, Kemp MC, McAnalley BH. American Society of Clinical Pathologists Fall Meeting, Dallas, Texas American Society of Clinical Pathologists Fall Meeting, Dallas, Texas, October 1990..
  46. A Report of Bacteria in Large Activated Circulating Macrophages on Peripheral Blood Smears Taken at or Near the Time of Blood Culture Collection. McDaniel HR ex, McDaniel HR. American Society of Clinical Pathologists Spring Meeting, Las Vegas, Nevada, April 1991.
  47. The Chernobyl Disaster: It’s Highlighting of Environmental Radionucleotide Incorporation in Organs: Acute and Chronic Treatment with an Emphasis on the Case of Children.  McDaniel HR.  Presented at the Dallas-Forth Worth Medical Center, Grand Prairie, Texas, September 26, 1992.
  48. CD4 and CD8 Lymphocyte Levels in Acemannan -Treated with HIV-a Infected Long-Term Survivors. McDaniel HR, Rosenberg LJ, McAnalley BH. IXth International Conference on AIDS/IV STD World Congress, Berlin, June 1993.
  49. The Basic Science and Principles for the Use of Acemannan in Clinical Practice. McDaniel HR. Great Lakes Association of Clinical Medicine, Inc., Chicago, Illinois, September 1994.
  50. The Aloe Mystery is Solved. Manapol did it! and The Inner Healer. A Method to Stimulate the Natural Process of Defense and Healing! McDaniel HR.  Presented at the Pasadena Health Show, Pasadena, California, January 1995
  51. Aloe/Fruits & Veggies – Phytochemical Revolution. McDaniel HR. Presented at the 4th Annual International Mayhaw Mania Conference and Workshops, Bridge City, Texas, April 1995.
  52. What Does Dioscorea Have to Offer? McDaniel HR. Presented at the 4th Annual International Mayhaw Mania Conference and Workshops, Bridge City, Texas, April 1995.
  53. Aloe Polymannose: An Essential Phytochemical for Optimal Health. McDaniel HR.  Presented at the 14th Annual International Symposium on Man and His Environment in Health and Disease.  Special Focus:  Environmental Aspects of Neurological and Cardiovascular Functions, February 1996.
  54. Ancient Wisdom: Phytochemicals Yesterday and Tomorrow. McDaniel HR.  Presented at Loma Linda University, Annual Alumni Health Seminar, February 1996.
  55. Phytochemicals: A Bright Light at the End of the Tunnel. McDaniel HR.  Section Chair, The Phytochemical Revolution.  The Second Annual International Congress on Alternative & Complementary, Alexandria, Virginia, June 1996.
  56. Power of Phytochemicals. Twentieth Annual Snake River Medical Forum, Lewiston, Idaho, June 1997
  57. Nutraceuticals: Phytonutritional support for endogenous synthesis of anti-oxidants and free-radical scavengers. McDaniel HR.  6th World Congress on Clinical Nutrition, Banff, Alberta, Canada, July 23-26, 1997.
  58. The DSHEA and its Impact on Pharmacy. McDaniel HR.  West Texas Pharmaceutical Association, 20th Annual Continuing Education, Lubbock, Texas, September 13-14, 1997.
  59. Nutraceutical Dietary Supplementation: the new scientific paradigm, the new law, an ancient power for healing. California State Osteopathic Medical Association Annual Meeting, Las Vegas, Nevada, March 1998.
  60. The Role of Nutraceuticals in the New Era of Nutritional Management of Compromised Health, Annual Pharmaceutical Meeting, New Mexico State Pharmaceutical Association, Platform Speaker for State Association, Albuquerque, N.M., April 1998.
  61. Preliminary Evidence Indicates that Nutraceutical Glyconutrient Dietary Supplementation Ameliorates Chronic Alcoholism, H.R. McDaniel, et. al. Indian Health Service 10th Annual Research Conference, Albuquerque, New Mexico, April 1998. (scientific poster)
  62. Glyconutrients Increase Reduced Glutathione Levels in Murine Liver Cells, H. R. McDaniel, et. al., Indian Health Service 10th Annual Research Conference, Albuquerque, New Mexico, April 1998. (scientific poster)
  63. The health promoting and healing power of mother’s milk, and taking nutrition back to the Garden of Eden. R. McDaniel, 1st National ADHD Convention July 11th, 1998, Hot Springs, Arkansas- Sponsored by ADD Success Group.
  64. The Science of Glyconutritional Dietary Supplementation, H.R. McDaniel, et. al, Australasian Society for Experimental Pathology, Twenty Ninth Annual Scientific Meeting, September 30 – October 2, 1998.
  65. Increased Intracellular Antioxidant Protection of Murine liver Cells is Induced by Glyconutrients, H.R. McDaniel, et. al., The 33rd Annual Meeting of the American Academy of Environmental Medicine, Baltimore, MD, Nov. 5-8, 1998
  66. Mobilization of Fat Soluble Toxins (Dioxins) are Induced by Dietary supplementation and a Herbal colon Cleanser Further Enhances Fecal Excretion of Toxins, H.R. McDaniel, et. al, The 33rd Annual Meeting of the American Academy of Environmental Medicine, Baltimore, MD, Nov. 5-8, 1998
  67. Bio-Markers of Aging are improved by a Nutraceutical-Augmented Optimal Health Plan, H.R. McDaniel, et. al., 6thInternational Congress on Anti-aging & Bio-Medical Technology, Las Vegas Nevada, Dec. 1998
  68. The Science of Glyconutritional Supplementation: A Rediscovery of Primal Components in Human Nutrition, H.R. McDaniel, et. al, 6th International Congress on Anti-Aging & Bio-Medical Technology, Las Vegas, Nevada, Dec. 1998
  69. Nutraceutical Dietary Supplementation Improves Clinical Status of Diabetics: A Retrospective Survey, H.R. McDaniel, et. al, 6th International Congress on Anti-Aging & Biomedical Technology, Las Vegas, Nevada, Dec 1998
  70. Glyconutrients Increase Intracellular – Reduced Glutathione Levels providing a potential for Prevention and Reversal of Degenerative Processes Associated with Diabetes and Aging, H.R. McDaniel, et. al, 6th International Congress on Anti-Aging & Biomedical Technology, Las Vegas, Nevada, Dec 1998
  71. Integrating nutraceuticals Into Your Pharmacy Practice. Michigan Pharmacists Association, Feb 20, 1999
  72. Integrating Nutraceuticals Into Your Pharmacy Practice, H.R. McDaniel, Michigan Pharmacists Assn., Lansing Michigan, April, 1999
  73. Biomarkers and Glyconutrition, Grand rounds, Dept. of Geriatrics, College of Medicine, Univ. of Arkansas Medical Sciences Center, August 4, 1999
  74. Latest Advances in Science, Glycobiology, Health and Immunity, 1999 Annual Mid-Year Conference, C.E. of Pharmacists and Pharmacy Technicians, Nov. 21, 1999, College of Pharmacy Univ. of Utah, Salt Lake City, Utah.
  75. Creditability, applicability, utility and need are fulfilled by Nutraceuticals, Annual Meeting of the National Convention of State Pharmacy Association.  Las Vegas, 1999
  76. A new horizon in optimal health and restoring health through use of nutraceuticals and herbs offers an unparalleled professional opportunity to health professionals, Washington State Pharmaceutical Association, British Columbia, Jan. 14-16, 2000
  77. Herbs and dietary supplements: an opportunity for the pharmacist. Michigan Pharmacists Association, Dearborn, Feb. 18-20, 2000.
  78. Grand Rounds Memorial Hospital, A renaissance in health and healing: nutraceutical containing dietary supplementation. Belleville, Illinois March 9, 2000.
  79. A challenge to health professionals: the dietary supplement health education act of 1994 offers means to promote new levels of health through use of nutraceuticals and herbs. Pediatric Conference, Univ. So. Alabama Children’s and Women’s Hospital, March 17, 2000. Syllabus available.
  80. Is There a Role for Dietary Supplementation in Combination with Standard Cancer Therapy? H. R. McDaniel, Comprehensive Cancer 2000, Arlington, Virginia, June 2000. Syllabus available.
  81. The Impact of Micronutrients of Childhood Behavior and Academics. R. McDaniel, W. Walsh, Staff presentation, Surgeon General’s Office, June 2000.
  82. General Antiviral Activity is Supported by Glyconutrient Dietary Supplementation. R. McDaniel,  Luis Romero, Hepatitis 2000, Miami, Florida, June 2000.
  83. Is There a Role for Nutraceutical Dietary Supplementation in the Care of Symptomatic HIV-1 Reactive Patients? R. McDaniel, ARONEVES and Reprising AIDS International, Miami, Florida, October 2000.
  84. Western Nutraceutical Research Confirms Reported Outcomes of a Soviet Program Demonstrating Superior Health and Performance Achieved Through Use of Micronutrient and Herbal Supplements, H. R. McDaniel, United Nations Food and Agriculture Organization, Pre-Conference for 17th Cong. Nutrition, Bratislava, Slovak Republic, August 2001
  85. Modern Dietary Supplementation Provides a Means to Improve Health Status in Mass Populations that is Safe, Effective, and Economical. R. McDaniel, Royal Society of Medicine, August 200l.  Syllabus available.
  86. A Nation’s Health Status Can be Improved by Safe, Effective, and Economical Dietary Supplementation, H.R. McDaniel, International Wellness Conference, University of Texas Medical Branch, Galveston, Texas, January 2002.
  87. Micronutrient Supplementation Initiates and Sustains an Improvement of Objective Biomarkers of Aging, H.R. McDaniel, G.R. Kaats, D.F. Busbee, C.F. McDaniel, American Holistic Medical Association Annual Meeting, Toronto, Ontario, March 2002. (Scientific poster)
  88. Diabetics Served as a Clinical Model to Evaluate Dietary Supplements Designed to Improve Biomarkers Associated with the Disabilities of Aging, F. McDaniel, G.R. Kaats, D. F. Busbee, H.R. McDaniel, American Holistic Medical Association Annual Meeting, Toronto, Ontario, March, 2002. (Scientific poster)
  89. AIDS Patient Responses Validate In Vitro Experiments Indicating Micronutrient Dietary Supplementation (DS) Supports Innate Antiviral Mechanisms and Restores Immune Function, H.R. McDaniel, M.D., C.F. McDaniel, D.O., Ed.D. 9th World Congress on Clinical Nutrition, June 2002, London, England (abst. Sci. poster and oral)
  90. An Emerging Paradigm: Dietary Supplementation Supports Optimal Human Health, introduction to Special Topical Supplement, Advances in Therapy, in press.
  91. Value of the Body Composition Improvement Index in Assessing the Safety and Efficacy of Weight-Loss Interventions, Gilbert R. Kaats, Samuel C. Keith, H. Reginald McDaniel. Special Topical Supplement, Advances in Therapy, in press.
  92. Effects of Short-term Experimental Interventions of Bone Mineral Density, Gilbert R. Kaats, Samuel C Keith, H. Reginald McDaniel, John A. Wise, Harry A. Croft, Dennis Pullin, William G. Squires Jr., Special Topical Supplement, Advances in Therapy, in press
  93. The Influence of Micronutrients on Quality of Life When Combined with Standard Therapy Protocols for Aggressive and Advanced Malignancies, DL Busbee, CF McDaniel, HR McDaniel, 1st Conf. Integ. Onco. Nov. 2004.
  94. The Impact of Glyconutients on the Immune Function, Conference on Innate Immune Defense, Defense Threat Reduction Agency- DOD, Lansdowne, Virginia, September 2005.
  95. Two Decades of Glycomics Basic Science and Clinical Research, Grand Rounds Hebrew University School of Medicine, Jerusalem, Israel and Visiting Lecture Technon, Haifa, Israel, November 2005.
  96. Glyconutrition in Alzheimer’s Disease: a pilot clinical survey, 1st Glycomics International Conference, Endowment for Medical Research, Octorber 2005, Houston, Texas
  97. Glyconutrition in Parkinson’s Disease: a pilot clinical survey, 2nd. Glycomics International Conference, Endowment for Medical Research, October 2006, Houston, Texas.
    • Response of Alzheimer’s Disease to extended micronutrition, 2nd. Glycomics International Conference, Endowment for Medical Research, October 2006, Houston, Texas
    • The Effect of an Aloe Polymannose Multinutrient Complex on Cognitive and Immune Functioning in Alzheimer’s Disease. of Alzhedimer’s Disease, 33 (3013) 393-406 DOI 10.3233/JAD-2013 393-406 IOS Press 393, Jan-FeB 2013.
  98. An Overview of Clinical Glycomics, Tokyo Society for Glycomics Study, October 2006. Tokyo, Japan University of Hiroshima.
  99. Enhancement of Natural Killer Cell Activity in Healthy Adults by Rice Bran Arabinoxylan
    Compound. John E. Lewis1, Ranjini Valiathan1,2, Angelica B. Melillo1, Susanna Leonard1, Deshran Asthana1,2, Judi Woolger3, Aaron H. Wolfson4, Janet Konefal1H. Reginald McDaniel5,
  100. Volume 2, Issue 7: 2012  Web Research Article (Open Access)
  101. The Effect of Dietary Supplementation on Brain Derived Neurotrophic Factor and Cognitive Functioning in Alzheimer’s Disease Co-Authorship, University of Miami Miller School of Medicine, Peer reviewed and due to be published.
  102. Journal of Alzheimer’s Disease 33 (2013) 393–406
    • DOI 10.3233/JAD-2012-121381 IOS Press 393
    • The Effect of an Aloe Polymannose
    • Multinutrient Complex on Cognitive andImmune Functioning in Alzheimer’s Diseas
  103. Journal of Clinical and Transitional Research, 3 (3)2017 Anti-Cancer Effects of Aloe-Emodin: A systematic review


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More Supporting Documentation:

20 Freeze, H. Disorders in protein glycosylation and potential therapy: Tip of an iceberg? J. Pediatrics.  1998; 133 (5): 595-600.

A Chemical Investigation of Aloe Barbadensis Miller; G.R. Waller, S. Mangiafico & C.R. Ritchey.

A Clinical Pilot Study Using Carrisyn in the Treatment of Acquired Immunodeficiency Syndrome (AIDS); H. Reg McDaniel,Sue Perkins & B.H. McAnalley.

A Comparative Investigation of Methods Used to Estimate Aloin & Related Compounds in Aloes.

A Drug for all Seasons Medical and Pharmacological History of Aloe; John S. Haller, Jr., Ph.D.

A Mucilage from Aloe Vera; Elizabeth Roboz & A.J. Haagen-Smit, Shu XO and others.

A population-based case-control study of childhood leukemia in Shanghai. Cancer 1988 Aug 1; 62(3):635-44.

A Phytochemical Study of Aloe Vera Leaf; Tom D. Rowe & Lloyd M. Parks.

AIDS and the Immune System; Warner C. Greene.

ASA, Aloe Vera Rx vs. Frostbite; Charlene Laino.

Acute Oral Toxicity Study (Dawson Research Corporation).

Acute Oral Toxicity Study of Aloe vera Powder in Rats (Dawson Research Corporation).

Advances in the Immunobiology of the Skin. Implications for Cutaneous Malignancies; Margaret L. Kripke & Cynthia A. Romerdahl.

Allergy and the Immune System; Lawrence M. Lichtenstein.

Aloctin A, an Active Substance of Aloe Arborescens Miller as an Immunomodulator; Ken’ichi Imanishi.

Aloe and Other Topical Antibacterial Agents in Wound Healing (Aloe Today, Fall/Winter 1993); John P. Heggers, Ph.D.

Aloe as an Ingredient; J.A. Magnuson.

Aloe Barbadensis Extracts Reduce the Production of Interleukin-10 After Exposure to Ultraviolet Radiation; Ronald P. Pelley, Ph.D., M.D.

Aloe Can Rise to the Challenge (Article for Aloe Today – Ronald P. Pelley, Ph.D., M.D.)

Aloe Drug May Mimic AZT Without Toxicity, Medical World News, December 1987 issue, Dr. H. Reginald McDaniel.

Aloe Medicinal Substances; Dr. Wendell Winters.

Aloe Polysaccharides and Their Measurement; Ronald P. Pelley, Ph.D., M.D.

Aloe species have been reported to have several biological activities, including: immunomodulation Suzuki, et al., 1979; Yoshimoto et al., 1987; Winters et al., 1981; Yagi et al, 1985; and Saito, 1993, enhancement of wound healing (Heggars, et al., 1993) and antiinflammatory actions (Davis et al., 1989).

Aloe Vera; Alexander G. Schauss.

Aloe Vera; Alan D. Klein & Neal S. Penneys.

Aloe Vera (Aloe Barbadensis Miller); Ivan E. Danhof, Ph.D., M.D.

Aloe Vera, Alan D. Klein, M.D., and Neal S. Penneys, M.D., Ph.D. Miami, FL; Journal of the American Academy of Dermatology. Volume 18, Number 4, Part I, pgs. 714-720, April 1988.

Aloe Vera – A Natural Approach for Treating Wounds, Edema, and Pain in Diabetes; Robert H. Davis, Ph.D., Mark G. Leitner, Joseph M. Russo.

Aloe Vera and Burn Wound Healing; Teddy Kaufman, A.R. Newman & M.R. Wexler.

Aloe Vera – Aloe Vera and Cancer, Dr. Lawrence G. Plaskett, B.A., Ph.D., C. Chem., F.R.I.C., Aloe Vera Information Service, Issue 6, Biomedical Information Services, Ltd., Cornwall.

Aloe Vera and Gibberellin Anti-Inflammatory Activity in Diabetes; Robert H. Davis, Ph.D. & Nicholas P. Maro.

Aloe Vera – Aloe Vera and the Four A’s Arthritis, Atheroma, Angina and Asthma, Dr. Lawrence G. Plaskett, B.A., Ph.D., C. Chem., F.R.I.C., Aloe Vera Information Service, Issue 15, Biomedical Information Services, Ltd., Cornwall.

Aloe Vera – Aloe and its Quality Control – Checking upon the Genuineness of Products, Dr. Lawrence G. Plaskett, B.A., Ph.D., C. Chem., F.R.I.C., Aloe Vera Information Service, Issue 11, Biomedical Information Services, Ltd., Cornwall.

Aloe Vera: Aloe Vera and Cancer, Aloe Vera and the Human Immune System, Aloe Vera and the Human Digestive System, Aloe Eases Inflammation, The Healing Properties of Aloe Vera, Aloe Vera: Aloe Vera in Alternative Medicine Practice, Aloe Eases Inflammation, Dr. G. Lawrence Plaskett.

Aloe Vera and Inflammation; Robert H. Davis, Joseph M. Kabbani & Nicholas P. Maro.

Aloe Vera and Wound Healing; Robert H. Davis, Joseph M. Kabbani & Nicholas P. Maro.

Aloe Vera Anti-Viral Agent; Ruth Adams.

Aloe Vera – The Carbohydrate Fraction of Aloe, Dr. Lawrence G. Plaskett, B.A., Ph.D., C. Chem., F.R.I.C., Aloe Vera Information Service, Issue 12, Biomedical Information Services, Ltd., Cornwall.

Aloe Vera and the Human Immune System, Dr. Lawrence Plaskett, B.A., Ph.D., C. Chem., F.R.S.C., The Aloe Vera Information Service, Issue I.

Aloe Vera and the Inflamed Synovial Pouch Model; Robert H. Davis, Greta J. Stewart, Peter J. Bregman.

Aloe vera (Aloe Barbadensis Miller), Internal Uses of Aloe Vera, Potential Benefits from Orally-Ingested Internal Aloe Vera Gel, Ivan E. Danhof, Ph.D, M.D.

Aloe Vera and the Human Digestive System, Lawrence Plaskett, B.A., Ph.D., C. Chem., F.R.S.C., Biomedical Information Services, Ltd., Cornwall.

Aloe Vera and the Human Digestive System, Aloe Eases Inflammation and Aloe Vera in Alternative Medicine; Lawrence Plaskett B.A., Ph.D., C. Chem., F.R.S.C.

Aloe Vera: Fact or Quakery; David C. Spoerke & Brent R. Ekins.

Aloe Vera For Burns; William F. Kivett, M.D.

Aloe Vera Gel and its Effect on Cell Growth; William B. Bowles.

Aloe Vera Gel: What is the Evidence? Judith M. Marshall.

Aloe Vera Gel in Peptic Ulcer Therapy: Preliminary Report Julian J. Blitz, D.O., James W. Smith, D.O. & Jack R. Gerardo, D.O., Dania, Florida; Journal of the American Osteopathic Association, Vol. 62, April 1963.

Aloe Vera Goes Maquila; Tony Vindell.

Aloe Vera, Hydrocortisone, and Sterol Influence on Wound Tensile Strengh and Anti-Inflammation; Robert H. Davis, Ph.D., Joseph J. Di Donato, B.S., Richard W.S. Johnson, Christopher B. Stewart.

Aloe Vera in the Treatment of Roentgen Ulcers & Telangiectasis; Carroll S. Wright. M.D.

Aloe Vera: Internal & External First Aid.

Aloe Vera is a Good Vehicle for Estrogens; Robert H. Davis, Ph.D., Joseph J. Di Donato, B.S.

Aloe Vera – It’s Chemical and Therapeutic Properties, Ronald M. Shelton, MAJ, USAF, MC; International Journal of Dermatology, October 1991.

Aloe Vera Open Wound Healing Micro-Assay; Robert H. Davis, Ph.D., Joseph J. Di Donato, B.S.

Aloe Vera Produces Anti-Inflammatory, Immune Strengthening Effects on Skin; Steven R. Schechter, N.D.

Aloe Vera Revered, Mysterious Healer (Health Food Business Magazine – Timothy R. Fox).

Aloe Vera, Salicylic Acid & Aspirin for Burns; Azriel Frumkin, M.D.

Aloe Vera: The Healing Plant, Stephen R. Schecter, N.D.

Aloe Vera the Miraculous Healer Lee Cowden, M.D. Health Consciousness, 1992, Vol. 13, No. 1, pp. 25. John C. Pittman, MD. Health Consciousness, 1992, Volume 13, No. 1, pp. 28-30.

Aloe Vera Rio Grande Valley Folks Claim It’s Good for What Ails You (Texas Highways Magazine).

Aloe Vera: Witchcraft or Wonder Drug? Martha A. Walton.

Aloe Versatile (Fort Worth Star Telegram).

Aloe’s effectiveness As an Antiinflammatory Agent Dr. Hiroko Saito, Dept. of pharmacy, Aichi Cancer Center, Nagoya, Japan. Aloe Today, Spring 1993.

Aloes in the Treatment of Burns and Scalds, J.E. Crewe, Md., Rochester, Minnesota.

Aloes of the World: A Checklist, Index and Code; Trevor B.D. Harding.

Amazing Aloe – This desert plant heals skin and much more, Karen France Unruh, Reprint: Tanning Trends, May 1989.

American Journal of Clinical Nutrition40 (4 Suppl): 927-30, Oct., 1984.Nair, P., et al.

“Amino acid metabolism in pediatric patients” Nutrition 14 (1): 143-8, Imura K., Okada A (1998).

An Anti-Complementary Polysaccharide with Immunological Adjuvant Activity from the Leaf Parenchyma Gel of Aloe Vera; L.A. ‘T Hart, A.J.J. Van Den Berg, L. Kuis, H. Van Dijk & R.P. Labadie.

Ancient Herb in New Form Delivers Proven Effects; Keisuke Fujita, M.D., Ph.D., Hidenhiko Beppu, Ph.D., Kaoru Kawai, Ph.D. & Kan Shinpo, Ph.D.

Angiogenesis inhibited by drinking tea. Nature. 1999; 398:381Cao Y, Cao R.

Anthraquinone Derivatives in Vegetable Laxatives; F.H.L. van Os.

Antibradykinin Active Material in Aloe Saponaria; Akira Yagi, Nobuo Harada, Hidenori Yamada, Shuichi Iwadare & Itsuo Nishioka.

Antidiabetic Activity of Aloe Vera Juice. Clinical Trial in New cases Of Diabetes mellitus; S. Yongchaiyudha, V. Rungpitarangsi, N. Bunyapraphtsara & O. Chokechaijaroenporn.

Antidiabetic activity of Aloe Vera L.Juice II. Clinical trial in new cases of diabetes mellitus, S. Yongchaiyudha, V. Rungpitarangsi, N. Bunyapraphatsara, and O. Chokechaijaroenporn; Phytomedicine Vol. 3(3), pp. 241-243, 1996: 1996 by Gustav Fischer Verlag, Stuttgart-Jen-New York.

Anti-inflammatory Activity and Wound Healing Activity of a Growth Substance in Aloe Vera, Anti-inflammatory Activity of Aloe Vera against a Spectrum of Irritants, Aloe Vera and Inflammation, The Conductor Orchestrator Concept of Aloe Vera, Aloe Vera Open Wound Healing Micro-Assay, Robert H. Davis, Ph.D, Joseph J. Di Donato, Glenn M. Hartman, Richard C. Haas.

Anti-inflammatory Activity of Aloe Vera Against A Spectrum of Irritants; Robert H. Davis, Ph.D., Mark G. Leitner, Joseph M. Russo, Megan E. Byrne.

Anti-inflammatory activity of extracts from Aloe vera gel; Beatriz Vazquez a, Guillermo Avila a, David Segura a, Bruno Escalante b Journal Ethnopharmacology 55 (1996) 69-75.

Anti-Inflammatory, Analgesic and Wound Healing Activity of Aloe Vera; Robert H. Davis, Ph.D.

Anti-inflammatory & Wound Healing Properties of Aloe Vera, Dr. Wendell Winters, et al.

Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am. J. Clin. Nutr., 53:194S-200S; Di Mascio, P., M. E. Murphy, and H. Sies. (1991).

Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr (VI)-induced DNA damage and Cr (IV)- or TPA-stimulated NF-Kappa B activation. Mol Cell Biochem. 2000; 206:125-132; Shi X, Ye J, Leonard SS, et al.

Antioxidants Winning the Fight for Good Health; Frank Murray.

Antioxidative Substances in Leaves of Polygonum Hydropiper; Hiroyuki Haraguchi, Kensuke Hashimoto & Akira Yagi.

Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate. Throm Res. 1999; 96:229-237; Kang WS, Lim IH, Yuk DY, et al.

Antiviral Activity of Aloe Extracts Against Cytomegalovirus; Dr. Wendell Winters.

Autoimmune Diseases; Lawrence Steinman.

Bacteriostatic Property of Aloe Vera; Lorna J. Lorenzetti, Rupert Salisbury, Jack Beal & Jack N. Baldwin.

Basis of Aloe Certification; Yin-Tung Wang, Ph.D.

Beneficial Effect of Aloe on Wound Healing in an Excisional Wound Model; Dr. Wendell Winters.

Beneficial Effects of Aloe in Wound Healing; John P. Heggers, Ronald P. Pelly & Martin C. Robson.

Beneficial Effects of Aloe on Wound Healing in an Excisional Wound Model; John P. Heggers, Ahmet Kucukcelebi, Dimitri Listengarten.

Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. Oncol Rep. 2003; 10(2):497-500. (PubMed); Awad AB, Roy R, Fink CS.

Beta-sitosterol activates the sphingomyelin cycle and induces apoptosis in NCaP human prostate cancer cells. Nutr Cancer. 1998;32(1):8-12. (PubMed); von Holtz RL, Fink CS, Awad AB.

Biochemical Properties of Carboxypeptidase in Aloe Arborescens Miller Var. Natalensis Berger; Shosuke Ito, Ryo Teradaira, Hidehiko Beppu, Masafumi Obata & Keisuke Fujita.

BIOFLAVINOIDS AND POLYPHENOLS: MEDICAL APPLICATIONS. Brian E. Leibovitz, Ph.D and Jennifer Ann Mueller, B.S.

Biological Activity of Aloe Vera; R.H. Davis.

Biological Standardization of Aloe Vera; Robert H. Davis, Ph.D.

Biologically Active Constituents of Leaves and Roots of Aloe Arborescens var. Natalensis; Toshifumi Hirata & Takayuki Suga.

Botanical Science Helps to Develop a New Relief For Human Suffering; Claud L. Horn.

Bradykinin-Degrading Glycoprotein in Aloe Arborescens var. Natalensis; Akira Yagi, Nobou Harada, Koichiro Shimomura & Itsuo Nishioka.

Bradykinninase Activity of Aloe Extract; Keisuke Fujita, Ryoji Teradaira & Toshiharu Nagatsu, Keisuke Fujita, Yasuo Yamada, Keizou Azuma & Susumu Hirozawa.

Cancer-Fighting Foods (Harvard Health Letter).

Cancer prevention by carotenoids. Mutat. Res., 402:159-163; Nishino, H. (1998)

Cancer Study Finds Sunscreen is Poor Shields; Gautam Nalk.

Carbohydrate Polymers From Aloe Ferox Leaves; Wilfred T. Mabusela, Alistair M. Stephen & Marthinus C. Botha.

Carotenoids: an overview. Meth. Enzymol., 213: 3-13; Pfander, H. (1992).

Carotenoids and the immune response. J. Nutr., 119:112-115; Bendich, A. (1989).

Carotenoid content of fruits and vegetables: an evaluation of analytic data. J. Am. Diet. Assoc., 93:284-296; Mangels, A.R., J.M. Holden, G.R. Beecher, M.R. Forman, and E. Lanza. (1993).

Carotenoids today and challenges for the future. In: Britton, G., S. Liaaen-Jensen, and H. Pfander [eds], Carotenoids vol. 1A: Isolation and Analysis. Basel: Birkhäuser; Britton, G., S. Liaaen-Jensen, and H. Pfander. (1995).

Carrington Gets USDA Approval to Market Drug to Veterinarians (The Dallas Morning News – Joe Simnacher).

Changes in prostanoid synthesis in response to diet and hypertension in one-kidney, one clip rats. Hypertension 1985; 7:886-92; Codde JP, McGowan HM, Vandongen R, Beilin LJ.

Changes of blood pressure in spontaneously hypertensive rats dependent on the quantity and quality of fat intake. Biomed.Biochim.Acta 1985; 44:1491-505; Moritz V, Singer P, Forster D, Berger I, Massow S.

Changes of N-6 and N-3 fatty acids in spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. Prostaglandins Leukot.Med. 1987;28:183-93; Singer P, Berger I, Gerhard U, Wirth M, Moritz V, Forster D.

Characteristics of Polysaccharides of Aloe Barbadensis Miller: Part III-Structure of an Acidic Oligosaccharide; Gaurhai Mandal, Rina Ghosh & Amalendu Das.

Chemical Characterization of the immunomodulating polysaccaride of Aloe Vera L; Jimmy Tai-Nin Chow, David A. Williamson, Kenneth M. Yates, Warren J. Goux.

Chemical Studies of Aloe Vera Juice II; G.D. Bouchy & Gunnar Gjerstad.

“Clinical Severity and Thermodynamic Effects of Iron-Responsive Element Mutations in Hereditary Hyperferritinemia-Cataract Syndrome.” Journal of Biological Chemistry 274 (1999): 26439–26447; Allerson, Charles R., M. Cazzola, and Tracey A. Rouault.

Comparative Studies of Aloe From Commercial Sources; Todd Waller.

Conformational Studies of Natural Products. III (*)Confomration of Natural 8-C-Glucosyl-7Hydroxy-5-Methylchromones & Their Derivatives (**); Paolo Manitto, Diego Monti & Giovanna Speranza.

Considerations for use of probiotic bacteria to modulate human health. J. Nutr. 2000: 130:384S-390S. Entrez PubMed 10721912, Sanders ME.

Current Status of Quality Control of Aloe Barbadensis Extracts; R.P. Pelley, Y.T. Wang & T.A. Waller.

Designing a Personal Care Product Using Aloe Vera; Todd Waller.

Determination of the Position of the O-Acetyle Group in a B-(1—–4_-Mannan (acemannan) from Aloe Barbadensis Miller; Sukumar Manna & Bill H. McAnalley.

Dietary antioxidant intake and risk of type 2 diabetes. DIABETES CARE (2): 362-366; Montonen J, Knekt P, Jarvinen R, et al. (2004).

Dietary fat intake and risk of lung cancer: a prospective study of 51,452 Norwegian men and women. Eur J Cancer Prev 1997 Dec;6(6):540-9; Veierod MG, Laake P, Thelle DS.

Dietary fish oil normalize dyslipidemia and glucose intolerance with unchanged insulin levels in rats fed a high sucrose diet. Biochim.Biophys.Acta 1996; 1299:175-82; Lombardo YB, Chicco A, D’Alessandro ME, Martinelli M, Soria A, Gutman R.

Dietary fish oil prevents dexamethasone induced hypertension in the rat. Clin Sci.(Lond) 1985;69:691-9; Codde JP, Beilin LJ.

Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis. Gut 1990; 31:539-44; Vilaseca J, Salas A, Guarner F, Rodriguez R, Martinez M, Malagelada JR.

Dietary manipulation in experimental inflammatory bowel disease. Agents Actions 1992; Spec No:C10-C14; Guarner F, Vilaseca J, Malagelada JR.

Different Effects of Native Candida Albicans Mannan & Mannan-Derived Oligosaccharides on Antigen-Stimulated Lymphoproliferation In Vitro; Raymond P. Podzorski, Gary R. Gray & Robert D. Nelson.

Does Aloe Vera Have Strogenic Activity? Robert H. Davis, Ph.D., Joseph J. Di Donato, B.S.

Effect of Aloe Barbedensis & Clofibrate on Serum Lipids in Triton-Induced Hyperlipidaemia in Presbytis Monkeys; V.P. Dixit & Suresh Joshi.

Effect of Aloe Extract on Peripheral Phagocytosis in Adult Bronchial Asthma, Takao Shida, Akira Yagi, Hiroshi Nishimura, and Itsuo Nishioka; Received: December 10, 1984; accepted: February 24, 1985; Planta Medica 1985.

Effect of Aloe Lectin on Deoxyribonucleic Acid Synthesis in Baby Hamster Kidney Cells; A. Yagi, K. Machii, H. Nishimura, T. Shida & I. Nishioka.

Effect of Amino Acids in Aloe Extract on Phagocytosis By Peripheral Neutrophil in Adult Bronchial Asthma, Akira Yagi.

Effect of Leaf Extracts of Aloe Arborescens Mill Subsp. Natalensis Berger on Growth of Trichophyton Metagrophytes; Keisuke Fujita, Ryoji Teradaira & Toshiharu Nagatsu, Keisuke Fujita, Yasuo Yamada, Keizou Azuma & Susumu Hirozawa.

Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res. 2001; 35:412-20. Entrez PubMed 11799281, Nase L, Hatakka K, Savilahti E, Saxelin M, Ponka A, Poussa T, Korpela R, Meurman JH.

Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised tiral. BMJ. 2001; 322:1327. Entrez PubMed 11387176, Hatakka K, Savilahti E, Ponka A, Meurman JH, Poussa T, Nase L, Saxelin M, Korpela R.

Effect of moderate levels of dietary fish oil on insulin secretion and sensitivity, and pancreas insulin content in normal rats. Ann.Nutr Metab 1996; 40:61-70; Chicco A, D’Alessandro ME, Karabatas L, Gutman R, Lombardo YB.

Effect of Orally Consumed Aloe vera Juice on Gastrointestinal Function in Normal Humans Jeffrey Bland, PhD, Linus Pauling Insittute of Science & Medicine, Palo Alto, California.

Effect of Preservatives on Aloe Vera Mucilage; A.H. Ghanem, A.F. Shalaby & M. Helal.

Effect of UV Irradiation on Lethal Infection of Mice with Candida Albicans; Margate L. Kripke & Y.M. Denkins.

Effects of Aloe Extracts on Human Normal and Tumor Cells in Vitro and Immunoreactive Lectins in Leaf Gel from Aloe Barbadensis Miller “Physiotherapy research”, Vol. 7, s23-s25 (1993) Wendell D. Winters W.D. Winters, R. Benevides, and W. J, Clouse Economic Botany, 35 (1), 1991, pp 89-95.

Effects of feeding various tocotrienol sources on plasma lipids and aortic atherosclerotic lesions in cholesterol-fed rabbits. FOOD RESEARCH INTERNATIONAL 35 (2-3): 245-251; Hasselwander O, Kramer K, Hoppe PP, et al. (2002).

Effects of Low Molecular Constituents from Aloe Vera Gel on Oxidative Metabolism and Cytotoxic and Bactericidal Activities of Human Neutrophils, L.A. T Hart, P.H. Nibbering, M.Th. Van Barselaar, H. van Dijk.

Effects of Ultraviolet-B Radiation on Human Health; Margaret L. Kripke, Dulloo AG, Duret C, Rohrer D, et al.

Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999; 70:1040-1045.

Enhancement of Aloe-Responsiveness of Human Lymphocytes by Acemmanan (Carrisyn); Debra Womble & J. Harold Helderman.

Enhancement of Two-Stage Skin Carcinogenesis by Exposure of Distant Skin to UV Radiation; Margaret L. Kripke, Paul T. Stickland & Donald Creasia.

Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli. O157:H7. Biochem Biophys Acta. 1999; 1472:42-50; Sugita-Konishi Y, Hara-Kudo Y, Amano F, et al.

Evaluation of Acemannan in the Treatment of Recurrent Aphthouse Stomatitis; Jacqueline M. Plemons, Terry D. Rees, William H. Binnie, John M. Wright, Ingrid Guo & John E. Hall.

Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am. J. Clin. Nutr., 62(suppl):1448S-1461S; Snodderly, D.M. (1995).

Experimental Use of Aloe Vera Extract in Clinical Practice; Robert B. Northway, D.V.M.

Folk Uses and Commercial Exploitation of Aloe Leaf Pulp; Julia F. Morton.

Food Technology, 47: 85-90, April 1993; Kinsella, J.E., et al.

Frostbite – Methods to Minimize Tissue Loss; J.P. Heggers, Robert L. McCauley & Martin C. Robson.

Further Studies of the Glucomannan from Aloe Vahombe (Liliaceae). II. Partial Hydrolyses & NMR 13C Studies; Farhad Radjabi-Nassab, Christine Ramiliarison, Claude Monneret & Erna Vilkas.

Gamma-Tocotrienol metabolism and antiproliferative effect in prostrate cancer cells. ANNALS OF NEW YORK ACADEMY OF SCIENCES 1031: 391-394; Conte E, Floridi A, Aisa C, et al. (2004).

Genotoxicity of Naturally Occuring Hydroxyanthraquinones; Johannes Westendorf, Hildegard Marquaradt, Barbara Poginsky, Marion Dominaik, Juergen Schmidt & Hans Marquardt.

Glycosylation and rheumatic disease Proceedings of the Royal Society of Medicine’s 5th Jenner Symposium, Axford J.S.

HPLC Analysis of Aloe – A Guarantee of Top Quality; Ronald P. Pelley, Ph.D., M.D.

Green tea and cancer chemoprevention. Mutation Res. 1999; 428:339-344; Suganuma M, Okabe S, Sueoka N, et al.

Green tea and skin — anticarcinogenic effects. J Invest Dermatol. 1994; 102:3-7; Mukhtar H, Katiyar SK, Agarwal R.

Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000; 24:252-258; Dulloo AG, Seydoux J, Girardier L, et al.

Green tea compounds inhibit tyrosine phosphorylation of PDGF beta-receptor and transformation of A172 human glioblastoma. FEBS Lett. 2000; 471:51-55; Sachinidis A, Seul C, Seewald S, et al.

Green tea polyphenols and cancer: biologic mechanisms and practical implications. Nutr Rev. 1999; 57:78-83; Ahmad N, Mukhtar H.

Green tea polyphenols (flavan 3-ols) prevent oxidative modification of low density lipoproteins: an ex vivo study in humans. J Nutr Biochem. 2000; 11:216-222; Miura Y, Chiba T, Miura S, et al.

Harper’s, Illustrated Biochemistry, 27th Edition, page 424-42, 436, 464, 618.

How Do They Grow Aloe? (Farm & Ranch Magazine).

How the Immune System Develops; Irving L. Weissman & Max D. Cooper.

How the Immune System Recognized Invaders; Charles A. Janeway, Jr.

How the Immune System Recognizes the Body; Phillippa Marrack & John W. Kappler.

Hydrogen Peroxide Metabolism in Human Monocytes During Differentiation in Vitro; Akira Nakagawara, Carl F. Nathan & Zanvil A. Cohn.

IASC Certification Healing Old Credibility Wounds (Aloe Today, Winter 1992 – Todd Waller).

Identification of Some Prostanoids in Aloe Vera Extracts; M. Afzal.

Immunological Consequences of UV-B Radiation; Margaret L. Kripke.

Immunological Effects of Ultraviolet Radiation; Margaret L. Kripke.

Immunology and Photocarcinogenesis; Margaret L. Kripke.

Immunoreactive Lectins in Leaf Gel From Aloe Barbadensis Miller; Wendell D. Winters.

Immunosuppressive Effect of Emodin, A Free Radical Generator; Huei-Chen Huang, Jin-Hsia Chang, Shiu-Feng Tung, Rong-Tsun Wu, Marie L. Foegh & Shu-Hsun Chu.

Impaired Immune Function in Patients with Xeroderma Pigmentosum; Margaret L. Kripke, Warwick L. Morison, Cora Bucana, Nemat Hashem, James E. Cleaver & James L. German.

Identification of (-)-epicatechin metabolites and their metabolic fate in the rat. Drug Metab Disp. 1999; 27:309-316; Okushio K, Suzuki M, Matsumoto N, et al.

Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. Int J Oncol. 2003;23(6):1657-1662. (PubMed); Choi YH, Kong KR, Kim YA, et al.

Infectious Diabetes; D. Kaufman and D. Holland, M.D.

Infectious Diseases & The Immune System; William E. Paul.

Influence of a cod liver oil diet in diabetics type I on fatty acid patterns and platelet aggregation. Biomed.Biochim.Acta 1984; 43:S351-S353; Schimke E, Hildebrandt R, Beitz J et al.

Influence of a cod liver oil diet in healthy and insulin-dependent diabetic volunteers on fatty acid pattern, inhibition of prostacyclin formation by low density lipoprotein (LDL) and platelet thromboxane. Klin.Wochenschr. 1986; 64:793-9; Beitz J, Schimke E, Liebaug U et al.

Inhibition of Arachidonic Acid Oxidation In Vitro by Vehicle Components; Neal S. Penneys.

Inhibition Of Aids Virus Replication By Acemannan In Vitro; Kahlon et al, 1991.

Inhibition of UV-Induced Immune Suppression and Interleukin-10 Production by Plant Oligosaccharides and Polysaccharides; Faith Strickland, Alan Darvill, Peter Albersheim, Stefab Ebergardm, Narcys Oaykt & Ronald Pelley.

Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation. Atherosclerosis. 2000; 148:67-73; Yang TTC, Koo MWL.

Inside Aloe Vera (Optimal Health Journal, Vol. 1, issue 4).

Internal Uses of Aloe Vera; Ivan E. Danhof, M.D., Ph.D., North Texas Medical Association.

Interview with Dr. Robert Picker, M.D., Public Scrutiny, May 1982, Vol. XXVII, No. 11.

Isolation and Characterization of the Glycoprotein Fraction with a Proliferation-Promoting Activty on Human and Hamster Cells in Vitro from Aloe Vera Gel; Akira Yagi, Taro Egusa, Mami Arase, Miyo Tanabe, Hiroshi Tsuji.

Isolation & Structure Analysis of a Glucomannan from the Leaves of Aloe Arborescens var. Miller; Thomas Wozniewski, Wolfgang Blaschek & Gerhard Franz.

Kids Who Shun Veggies Risk III Health Later (USA Today – Tim Friend).

Life Extension, March 2007

Long-term effect of eicosapentaenoic acid ethyl (EPA-E) on albuminuria of non-insulin dependent diabetic patients. Diabetes Res.Clin Pract. 1995; 28:35-40; Shimizu H, Ohtani K, Tanaka Y, Sato N, Mori M, Shimomura Y.

Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys., 274:532-538; Di Mascio, P., Kaiser, S., and Sies, H. (1989)

Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta. 2000; 1478:51-60; Demeule M, Brossard M, Pagé, M, et al.

Mechanism of Anti-Inflammatory & Anti-Thermal Burn action of Aloe Arborescens Mill. Var. Natalensis Berger; Masafumi Obata, Shosuke Ito, Hidehiko Beppu & Keisuke Fujita.

Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhea. Ailment Pharmacol Ther. 2002; 16: 1461-1467 Entrez PubMed 12182746, Cremonini F, Di Caro S, Nista EC, Bartolozzi F, Capelli G, Gasbarrini G, Gasbarrini A.

Mineral Analyses of Vegetarian, Health, and Conventional Foods: Magnesium, Zinc, Copper and Manganese Content; Deborah A. McNeill, Perveen S. Ali & Young S. Song.

Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994:326-41; Farrell P and Roberts R. Vitamin E. In: Shils M, Olson JA, and Shike M, ed.

Modern Nutrition in Health and Disease. 10th ed. Baltimore: Williams & Wilkins, 1999:347-62; Traber MG. Vitamin E. In: Shils ME, Olson JA, Shike M, Ross AC, ed.

Molecular Biology of the Cell. 3d ed. New York: Garland, 2002; Alberts, Bruce, et al.

Morphology & Anatomy in Aloinae. I Gasteria Verrucosa (Mill) Haworth; Mogens Wellendorf.

Multiparameter Analysis of Aloe Barbadensis Gel Extracts; Ronald P. Pelley, Ph.D., M.D.

[Multiple actions of EGCG, the main component of green tea]. [Article in French]. Bull Cancer. 1999; 86:721-724; L’Allemain G.

My Favorite Plant Aloe Vera; Gayle Gates.

Myth, Magic, Witchcraft or Fact? Aloe Vera Revisited; John P. Heggers  Martin C. Robson.

Natural sources of carotenoids from plants and oils. Meth. Enzymol., 213: 142-167; Ong, A.S.H., and E.S. Tee. (1992).

“Neuroprotective properties of the natural vitamin E alpha-tocotrienol.” Stroke 36 (10): 2258-64. PMID 16166580; Khanna S, Roy S, Slivka A, Craft T, Chaki S, Rink C, Notestine M, DeVries A, Parinandi N, Sen C (2005).

New carotenoids: recent progress. Invited Lecture 2. Abstracts of the 12th International Carotenoid Symposium, Cairns, Australia, July 1999; Mercadante, A. (1999).

New Uses for Aloe Vera (Natural Health Magazine – Karen Barr).

“Nutrient Receptors and Gene Expression.” In Nutrition and Gene Expression, edited by Carolyn D. Berdanier and James L. Hargrove. Boca Raton, Fla.: CRC Press, 1993; Berdanier, Carolyn D., and James L. Hargrove.

Panacea or Old Wives’ Tales? Ellis G. Bovik, D.D.S., M.S.D.

Partial normalization by dietary cod liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria. N.Engl.J Med. 1989;321:1572-7; Jensen T, Stender S, Goldstein K, Holmer G, Deckert T.

Partial Purification and Some Properties of an Antibacterial Compound from Aloe Vera; Hadassa Levin, R. Hazenfratz, J. Friedman, D. Palevitch & M. Perl.

Pharmacological Studies on a Plant Lectin, Aloctin A.I. Growth inhibition of Mouse Methyl.

Plasma concentration of carotenoids after large doses of beta-carotene. Am. J. Clin. Nutr., Sep 52:3, 500-1; Mathews-Roth, MM. (1990).

Polypeptides of Aloe Barbadensis Miller, Effects of Aloe Extracts of Human Normal and Tumor Cells, Immunoreactive Lectins in Leaf gel From Aloe Barbadensis Miller, S. L. Udupa, A. L. Udupa & D. R. Kulkarni.cholanthrene-Induced Fibrosarcoma: K. Imanishi, T. Ishiguro, H. Saito & I. Suzuki.

Polypeptides of Aloe Barbadensis Miller; Dr. Wendell Winters & Pamela B. Yang.

“Post-Transcriptional Control via Iron-Responsive Elements: The Impact of Aberrations in Hereditary Disease.” Mutation Research 437 (1999): 219–230; Mikulits, Wolfgang, Matthias Schranzhofer, Hartmut Beug, and Ernst W. Müllner.

Potential Benefits from Orally-ingested internal Aloe Vera Gel; Ivan E. Danhoff, Ph.D., M.D.

“Potential Mechanisms of Metabolic Imprinting that Lead to Chronic Disease.” American Journal of Clinical Nutrition 69 (1999): 179–197; Waterland, Robert A., and Cutberto Garza.

Potential uses of probiotics in clinical practice. Clin Microbiol Rev. 2003; 16:658-72. Entrez PubMed 14557292, Reid G, Jass J, Sebulsky MT, McCormick JK.

Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Archives of General Psychiatry, 2005 Jun;62(6):617-27; Kessler RC, Chiu WT, Demler O, Walters EE.

Prevention of Atheromateous Heart Disease,1985 Aloe’s blood glucose lowering, cholesterol and triglyceride lowering effects, O.P. Agarwal, M.D., F.I.C.A., Uttar Pradesh, India: Angiology; Volume 36, Number 8, August 1985 – The Journal of Vascular Diseases Published twelve times a year under the auspices of Westminster Publications, Inc.

Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA. 1999; 96:4524-4529; Haqqi TM, Anthony DD, Gupta S, et al.

Principles of Wound Healing and Growth Factor Considerations; Stephen J. Skokan, B.S. & Robert H. Davis, Ph.D.

Probiotics an overview of beneficial effects. Antonie Van Leeuwenhoek. 2002; 82:279-89. Entrez PubMed 12369194, Ouwehand AC, Salminen S, Isolauri E.

Probiotics and prevention of atopic disease: 4-year follow-up of a randomized placebo-controlled trial Lancet. 2003; 361:1869-1871. Entrez PubMed 12788576, Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri E.

Probiotic bacteria in the management of atopic disease: underscoring the importance of viability. J Pediatr Gastroenterol Nutr. 2003; 36:223-227 Entrez PubMed 12548058, Kirjavainen PV, Salminen SJ, Isolauri E.

Probiotic lactobacilli: an innovative tool to correct the malabsorption syndrome of vegetarians? Med Hypotheses. 2005; 65(6):1132-5. Entrez  PubMed 16095846, Famularo G, De Simone C, Pandey V, Sahu AR, Minisola G.

Processed Aloe Vera Administered Topically Inhibits Inflammation; Gregory A. Rouw.

Prostaglandins & Thromboxane; John P. Heggers & Martin C. Robson.

Prostanoid Derivatives in Thermal Injury; John P. Heggers & Martin C. Robson.

Prostate cancer chemoprevention by green tea. Semin Urol Oncol. 1999; 17:70-76; Gupta S, Ahmad N, Mukhtar H.

Purification & Characterization of a Gliuthathione Peroxidase from theAloe Vera Plant; F. Sabeh, T. Wright & S.J. Norton.

Purification & Characterization of Two Lectins from Aloe Arborescens Mill; Ikuo Suzuki, Hiroko Saito, Shigeki Inoue, Shunsuke Migita & Taijo Takahashi.

Purification of a Glutathione Peroxidase from the Aloe Vera Plant, F. Sabeh, T. Wright, & S. J. Norton.

Race is on to Develop Sugar-Based Anti-inflammatory, Antitumor Drugs; Stu Borman.

Reduced Gluthathione as an Effector of Phosphoenolpyruvate Carboxylase of the Crassulacean Acid Metabolism Plant Sedum Praealtum D.C.; Yiannis Manetas and Nikos A. Gavalas.

Retardation of the Ageing Process in Rats by Food Restriction, B. P. Yu, E.J. Masoro, I. Shimokawa .

Reversal of UVB-Induced Suppression of Contact Sensitivity in C3H Mice by Topical Administration of Aloe Barbadensis Gel Extracts; Faith Strickland, Ronald Pelley, Donald Hill & Margaret Kripke.

Roentgen Dermatitis Treated with Fresh Whole Leaf Aloe Vera; C.F. Collins, D.D.S., M.D. & Creston Collins, M.S.

Say Aloe to an Age Old Remedy (Fort Worth Star Telegram).

Scientist Helps Hasten the Healing of Young and Old (Fort Worth Star – Steve Gariepy).

Screening of Natural Sources for Antiinflammatory Activity (Review); B. Sener & F. Bingol.

Secrets of Long Life, New York, Devin-Adair Publishers, 1993; Walker, Morton.

Skin Cancer Cases Climbing, Experts Say (The Dallas Morning News – Laura Bell).

Skin Penetration of Mucilage and Aloe Vera; Robert H. Davis, Ph.D.

Some External Uses of Aloe; Ivan E. Danhof, Ph.D., M.D.

Some Sunscreens may be ineffective, Study Finds (Chicago Tribune – Jan. 19, 1994 – Scripps Howard).

Soothing Succulent Aloe Vera (Texas Highway Magazine, Janet Edwards, Jan. 98).

Stabilized Aloe Vera: Effect on Human Skin Cells; Ivan E. Danhof Ph.D., M.D. & Bill H. McAnnaley, Ph.D.

Sterol transporters: targets of natural sterols and new lipid lowering drugs. Pharmacol Ther. 2005; 105(3):333-341. (PubMed) ; Sudhop T, Lutjohann D, von Bergmann K.

Stimulation of Neuron-like Cell Growth by Aloe Substances; Dr. Wendell Winters, Catherine Bouther, Virgil Schirf.

Stimulation of Primary Rate Hepatocytes; Hans Marquardt.

Structure and properties of carotenoids in relation to function. FASEB J., 9:1551-1558; Britton, G. (1995).

Structure Determination of Polysaccharides in Aloe Arborescens var. Natalensis; Akira Yagi, Hiroshi Nishimura, Takao Shida & Itsu Nishioka.

Structure of the D-Galactan Isolated from Aloe Barbadensis Miller; Gaurhai Mandal & Amalendu Das.

Structure of the Glucomannan Isolated From The Leaves of Aloe Barbadensis Miller; Gaurhai Mandal & Amalendu Das.

Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol. 2000; 13:177-184; Li C, Lee M-J, Sheng S, et al.

Structural Studies of Polysaccharides from Aloe Vera; D. Channe Gowda, Belkavadi Neelisiddaiah & Yernool V. Anjaneyalu.

Structural Studies of the Glucomannan from Aloe Vahombe; Farhad Radjabi, Claudine Amar & Erna Vilkas.

Structural Studies of the Polysaccharide from Aloe Plicatilis Miller; Berit Smestad Paulsen, Egil Fagerheim & Elna Overbye.

Structural Study of an Acidic Polysaccharide Isolated From Aloe Arborescens Mill. I. Periodate Oxidation & Partial Acid Hydrolysis; Mirjana Hranisavljevic-Jakovljevic & Jelena Miljkovic-Stojanovic.

Studies on Alysis of Organic Acids & Amino Acids in Various Aloe Species; Masaaki Ishikawa, Masatoshi Yamamoto & Toshio Masui.

Studies on Glucogalactomannan from the Leaves of Aloe Vera Tourn. (EX.LINN.); Q.N. Hag and A. Hannan.

Studies on the Constituents of Aloe Arborescens Mill. Var. Natalensis Berger. I. The Structures of Two New Aleosin Esters; Kenji Makino, Akira Yagi & Itsuo Nishioka.

Studies on the Constituents of Aloe Arborescens Mill. Var. Natalensis Berger. II. The Structures of Two New Aleosin Esters; Kenji Makino, Akira Yagi & Itsuo Nishioka.

Study Shows Aloe Prolongs Life, Decreases Incidence of Disease (Nexus May/June 1997).

Sugar Composition in Macromolecular Fraction from Aloe Vera; Akira Yagi.

Sun and Ultraviolet Ray Exposure; Margaret L. Kripke.

Targeted Delivery of Superoxide Dismutase to Macrophages Via Mannose Receptor-Mediated Mechanism, Yoshinobu Takakura, Sada Masuda, Hikeaki Tokuda, Makiya Nishikawa & Mitsuru Hashida.

Tea catechin supplementation increases antioxidant capacity and prevents phospholipid hydroperoxidation in plasma of humans. J Agric Food Chem. 1999; 47:3967-3973; Nakagawa K, Ninomiya M, Okubo T, et al.

The Aloe Alternative; Bruce Magness.

The Aloe Vera Phenomenon: A review of the Properties and Modern Uses of the Leaf Parenchyma Gel; Douglas Grindlay & T. Reynolds.

The Art and Science of Burn Care; John A. Boswick, Jr., MD, FACS.

The Compounds in Aloe Leaf Exudates: A Review; T. Reynolds.

The Conductor-Orchestra Concept of Aloe Vera; Robert H. Davis, Ph.D., Scientific Advisor and Research Consultant, Aloecorp, Professor Emeritus of Physiology, Pennsylvania College of Podiatric Medicine.

The Current Status of Aloe Vera Research; William B. Bowles.

The Drug Aloes of Commerce, With Special Reference to the Cape Species; W.H. Hodge.

The Efficacy of the Aloe Plants Chemical Constituents and Biological Activities; Takayuki Suga, Toshifumi Hirata.

The Evaluation of Natural Substances in the Treatment of Adjuvant Arthritis; Denice C. Hanley, William A.B. Solomon, Barry Saffran & Robert H. Davis, Ph.D.

The Evolution of Aloes: New Clues from their Leaf Chemistry; AM Cviljoen & B-E van Wyk.

The External Use of Aloes, J.E. Crewe, M.D.

The Glucomannan Sytem From Aloe Vahombe (Lilliaceae). III. Comparative Studies on the Glucomannan Components Isolated from the Leaves; Erna Vilkas & Farhad Radjabi-Nassab.

The Healing Power of the Aloe Vera (New Women Magazine – Bargyla Ratceaver, Ph.D.).

The How, Where, and What of Good Aloe, Dr. Reginald McDaniel.

The Immune System as a Therapeutic Agent; Hans Wigzell.

The Immunology of Skin Cancer; Margaret L. Kripke.

The Isolation of an Active Inhibitory System from an Extract of Aloe Vera; Robert H. Davis, Ph.D., William L. Parker, B.A., Richard T. Samson, B.S. & Douglas P. Murdoch, B.S., Kenneth Y. Rosenthal, Linda R. Cesario.

“The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis.” Annual Review of Cellular and Developmental Biology 16 (2000): 459–481; Repa, Joyce J., and David J. Mangelsdorf.

The role of probiotics in the treatment and prevention of Helicobacter pylori infection. Int J Antimicrob Agents. 2003; 22:360-366. Entrez PubMed 14522098, Hamilton-Miller JM.

The Role of Topical Agents in the Healing of Full Thickness Wounds; Melissa A. Watcher, M.D., Ronald G. Wheeland, M.D.

The Soothing Aloe Vera Plant (Delicious Magazine, Sept. 1997 – Sue Woodard).

The Stimulation of Postdermabrasion Wound Healing with Stabilized Aloe Vera Gel-Polyethylene Oxide Dressing; James E. Fulton, Jr., M.D., Ph.D.

The Therapeutic Efficacy of Aloe Vera Cream (Dermaide Aloe) in Thermal Injuries: Two Case Reports; Lee M. Cera, John P. Heggers, Martin C. Robson, William J. Hagstrom.

The World Health Organization. The World Health Report 2004: Changing History, Annex Table 3: Burden of disease in DALYs by cause, sex, and mortality stratum in WHO regions, estimates for 2002. Geneva: WHO, 2004.

Therapeutic Protocol for Thermally Injured Animals & its Successful Use in an Extensively Burned Rhesus Monkey; Lee M. Cera, John P. Heggers, William J. Hagstrom & Martin C. Robson.

Therapy & Treatment with Aloe Vera; Frank Murray.

Three Chromone Components from Aloe Vera Leaves; Nobuyuki Okamura, Noriko Hine, Toshihiro Fujioka, Kunihide.

Tissue Culture of Aloe Arborescens Miller var. Natalensis Berger; Kaoru Kawai, Hidehiko Beppu, Takaaki Koike & Keisuke Fujita.

Tocotrienol-rich fraction from palm oil and gene expression in human breast cancer cells. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1031: 143-157; Nesaretnam K, Ambra R, Selvaduray KR, et al. (2004).

Topical Anti-Inflammatory Activity of Aloe Vera as Measured by Ear Swelling; Robert H. Davis, Mark G. Leitner, Joseph M. Russo.

Topical Effect of Aloe with Ribonucleic Acid and Vitamin C on Adjuvant Arthritis; Robert H. Davis, Ph.D., Eugene Shapiro, Patrick S. Agnew.

Treating Injuries with Aloe Vera (Runners World/Jan. 1993 – Chuck Piper w/Kevin Baxter).

Two Functionally and Chemically Distinct Immunomodulatory Compounds in the Gel of Aloe Vera , L.A. T Hart, Van Enckevort, H. van Dijk, R. Zaat, K. de Silva & R.P. van Dijk.

Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia 2000; 43:1093-8; Stene LC, Ulriksen J, Magnus P, Joner G.

U.S. scientists extend the life of human cells, British Medical Journal, Jan, 1998

U.S. Department of Agriculture, Agricultural Research Service. 2004. USDA National Nutrient Database for Standard Reference, Release 16-1. Nutrient Data Laboratory Home.

Uses of Aloe in Treating Leg Ulcers and Dermatoses; M. El Zawahry, M.D., M. Rashad Hegazy, M.D. & M. Helal, B.Ph.

Vasorelaxants from Chinese Herbs, Emodin and Scoparone, Possess Immunosuppressive Properties; Huei-Chen Huang, Shu-Hsun Chu & Pei-Dawn Lee Chao.

Vitamin A as “anti-infective” therapy, 1920-1940. J Nutr 1999; 129:783-91; Semba RD.

Vitamin E: Beyond antioxidant function. Am J Clin Nutr 1995; 62:1501S-9S; Traber MG and Packer L.

Why drinking green tea could prevent cancer. Nature. 1997; 387:561; Jankun J, Selman SH, Swiercz R, Skrzypczak-Jankun E.

Wound Healing – Oral and Topical Activity of Aloe Vera; Robert H. Davis, Ph.D. Mark G. Leitner, RPh, DPM, Joseph M. Russo, DPM & Megan E. Byrne, B.S.

Wound Healing Potential of Aloe and Other Chemotherapeutic Agents; John P. Heggers, Ahmet Kucukcelebi, Catherine J. Stabenau, Francis Ko, Lyle D. Broemeling, Wendell Winters, Catherine Bouthet and Martin C. Robson.

“Incurable” Diseases can now be HEALED! Chronic Autoimmune Conditions can now be eliminated by restoring ACCURACY to the IMMUNE SYSTEM, and allowing IMMUNITY to heal the body.

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NATURAL HEALING – WWW.DRRONDRUCKER.COM

Dr. Ronald P. Drucker teaches natural healing breakthrough: Proper Immune Activation Eliminates 100+ Diseases classified as “incurable” by the drug-based medical community.

Dr. Drucker is a natural healing physician with 21 years of experience in healing Autoimmune Conditions, spreading the word about healing Autoimmune Conditions, and teaching other physicians how to heal autoimmune conditions. “I am able to openly teach any individual or practitioner, and spread the word that these “incurable conditions” are indeed very easily healed, because I am an independent who is not selling drugs or supplements, and who is not being compensated by any party who is. I am referring the individual and practitioner to a healing procedure, and I am charging no fees to do so.”

Dr. Ronald P. Drucker, B.S.M.T. (A.S.C.P.), D.C.
By extracting, stabilizing, and concentrating the active healing ingredients in aloe, DigestaCure® AUTOIMMUNE-X® contains over Sixty Eight (68) times the active healing ingredients compared to any other product, as confirmed via independent size-exclusion chromatography testing. NOTHING Comes Close to The Endless Health Benefits of DigestaCure® AUTOIMMUNE-X®

From the Published Research Studies, and my direct experience, the active ingredients in DigestaCure® AUTOIMMUNE-X®:

  • Are incorporated into the cell membranes throughout the body, enhancing the membranes effectiveness regarding a number of known functions.
  • Create a dramatic overall improvement of the assimilation of nutrients through the digestive tract, AND the intake of nutrients through the cell membranes.
  • Help stop and prevent the damage and leakage of the intestinal wall (leaky-gut syndrome), thereby alleviating the stress from the immune system.
  • Protect the mucous membranes lining the respiratory, gastrointestinal, and genitourinary tracts resulting in an increased resistance to infections, irritations, inflammation, and subsequently tissue lining degeneration.
  • Restore the glycocalyx coatings on the surfaces of killer cells enabling the killer cells to identify disease causing germs and destroy them, instead of blindly attacking the tissues of the body (Anti-Autoimmunity).
  • Provide much of the language (coding) of The Code of Life for cellular recognition, intracellular communication, and communication between cells (intercellular) and the immune system.
  • Possess immune modulating and immune stimulating effects. Stimulate accurate antibody production (by leukocytes) and an increase in the number of accurate killer T-cells produced. This expresses the tremendous importance in these immune stimulating functions. The levels of accurate antibodies present in our blood directly affects our ability to destroy pathogenic (disease causing) organisms. The killer T-cells are among our first line of defense in destroying dangerous bacteria and viruses and may even protect us from those responsible for an array of cancers.
  • Possess anti-inflammatory functions particularly effective in autoimmune diseases, due in part to the specific inhibition of leukotriene B-4, a highly pro-inflammatory substance.
  • Are likely to reduce the incidence of cancer, stroke, and heart disease, along with all autoimmune diseases. This is due primarily to the scientifically established fact that chronic inflammation increases the incidence of these conditions.
  • Contain antioxidant and free radical scavengers. The importance of antioxidants to overall health and longevity is profound. Antioxidants prevent the destruction of DNA by protecting the strands form the free radicals responsible for the destruction of DNA. Research indicates that the amounts and quality of antioxidants we consume are directly proportional to how long we will live and the quality of our lives.
  • Enhance the excretion of toxins from the cells, both intracellular and extracellular, by a unique process known as exocytosis.
  • Possess anti-viral, anti-bacterial, anti-yeast, anti-fungal, anti-mold, and anti-parasitic effects which are of particular interest especially today, linked to the increased incidence of antibiotic resistant strains of pathogens that are no longer responsive to treatment. This further establishes why the ingestion of these active ingredients are so helpful in preventing, normalizing, and correcting so many digestive tract disorders.
  • Possess hypoglycemic and blood sugar normalizing functions in both Type I and Type II diabetics.
  • Contain an insulin-like growth factor that lowers the required amount of insulin needed to maintain normal blood sugar levels.
  • Reduce the amount of insulin needed, thereby reducing cardiovascular risk factors and stress on the pancreas and likely increasing its useful life.
  • Enhance chemotaxis, the migration of immune cells to a site of injury or infection, eliminating infections, and thereby initiating the repair and healing response; promoting tissue growth and regeneration.
  • Support and Protect the Endothelial Glycocalyx, the critical lining protecting the arteries. See Below:

Stem cell therapy doctors are finding that patients taking DigestaCure® AUTOIMMUNE-X® over periods of months, possess up to 1000% (Ten Times) Higher Healthy Stem Cell Counts.

Stem Cells Can Heal and Regenerate

Stem cells are the foundation cells for our bodies. These highly specialized cells that make up our organs and tissues, originally came from an initial pool of stem cells that formed shortly after fertilization. Throughout our lives, we continue to rely on persisting stem cells to repair injured tissues and replace cells that are lost every day, such as those in our skin, hair, blood, muscles, nerves, lining of our gut, brain and all other the organs and glands.

For centuries, men of medicine were under the assumption that when injury, such as a cut through the skin, fat and muscle occurred, that by cleaning and binding the wound together, the muscles and skin would grow into each other, thus healing the wound. By the 1960s, with the help from microscopes and modern technology, man discovered that it was actually stem cells filling the gap of the wound, “differentiating” or transforming themselves into muscle, fat, and skin cells needed to mend the wound.

Dr. Melvin M. Propis, M.D.: “In all my years of performing stem cell therapies, I have never witnessed healthy adult stem cell counts coming close to those patients who had been taking DigestaCure® AUTOIMMUNE-X®. I am now taking the AUTOIMMUNE-X myself, and recommend it to every appropriate patient before and after stem cell therapy. I believe it creates a Total Body Homeostasis, conducive for strong healthy adult stem cell replication.”

Dr. Melvin M. Propis, M.D., of Plantation, Florida is highly regarded as one of the Nations’ Top Stem Cell Therapy Practitioners.
Call Dr. Propis for a consultation Today: 954-587-7600. Office address: 333 N.W. 70th Avenue – Suite 201 – Plantation, FL 33317

How Powerful are They? Can Stem Cells Heal Damage as Severe as Paralyzation?

When Kristopher Boesen of Bakersfield regained consciousness after losing control of his car while driving in wet conditions, he was paralyzed from the neck down. The prognosis was grim: he was told that he might never regain control of his limbs again.

But he has. At least some of them. He has movement in his upper body and can use his arms and hands. He can feed himself, text friends and family and even hug them. To him, this means that he has his life back. How did this miracle come about?

Kris was offered the opportunity to participate in a human clinical trial at the University of Southern California and Asterias Biotherapeutics. He is one of five previously paralyzed patients who experienced increased mobility after being treated with Stem Cells.

Practitioners are discovering that DigestaCure® AUTOIMMUNE-X® aggressively promotes an environment of Total Body Homeostasis.
By Andrea Larsen, Licensed Nutritional Consultant

Total Body Homeostasis or Total Physiologic Stability is a bodily status where all Systems, Organs, and Cells are functioning perfectly as designed, without interference from physiologic stress, disease, or premature aging (deterioration).

Homeostasis is characteristic of a system that regulates its internal environment and maintains a stable, relatively constant condition of properties. It is a state where all bodily parameters and markers exist within a normal range of values. This is the proverbial “State of Perfect Health.”

Total Body Homeostasis is key to life, and failures in homeostasis can lead to hundreds of various diseases, and premature aging. Homeostasis can be defined as an Ease or normalcy of bodily functions and processes. Disease or Dis-Ease can be defined as trouble, – the lack of Ease.

In my 35 years of experience, I have continually witnessed that many patients can ingest all of the best foods and quality supplements available, never reach Homeostasis, and still fall victim to disease and premature aging.

Imagine ingesting One Substance, containing the properties which create the very foundation necessary for Total Body Homeostasis, whereupon all other quality substances ingested then may have access to perform their individual benefits. I have found this substance to be DigestaCure® AUTOIMMUNE-X®, and the healings I have accomplished in the last 2 years I have used it with patients, far outweigh all of the former.

A successful innovator, educator, and lecturer in the fields of holistic health and natural healing for over 35 years, Andrea Larsen is highly regarded among the top authorities on nutrition and healing in South Florida. As an integrative practitioner utilizing a complementary approach, her goal is to promote your health and happiness by providing individualized programs to support your total wellness.

Contact Andrea Larsen: Tel: 305-895-5533 email: info@ultimate-nutrition.net

Causeway Square Building, 1801 NE 123rd Street, Suite 314, North Miami, FL 33181

 

Dr. Derrick DeSilva, M.D., and Dr. Jeffrey Gladden, MD, FACC throw new light on the question by looking at the endothelial glycocalyx. That’s the microscopic film covering and protecting the vascular endothelium within the arteries.

“It is the clotting in response to plaque disruption, not the plaque accumulation in the arteries per se that poses the real threat. 75% of heart attacks occur at arteries that are less than 50% blocked…”

“To protect endothelial function, we must support its existing natural protection, the endothelial glycocalyx.”

International Journal of Biological Sciences: “Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key function of participating in the maintenance of patent and functional capillaries. The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, venous thrombosis, and severe viral infectious diseases. Dysfunction of the vascular endothelium is thus a hallmark of human diseases.” Int J Biol Sci. 2013; 9(10): 1057–1069.

The endothelial glycocalyx protective linings are made up of and supported by the glycoproteins and other stabilized components found in DigestaCure® AUTOIMMUNE-X®.